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MicroRNAs in vascular remodeling and repair
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Howard, Lynsey, Caporali, Andrea, Shantikumar, Saran and Emanueli, Costanza (2015) MicroRNAs in vascular remodeling and repair. In: Sen, Chandan K. , (ed.) MicroRNA in Regenerative Medicine. Elsevier, pp. 601-629.
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Official URL: http://dx.doi.org/10.1016/B978-0-12-405544-5.00023...
Abstract
At the heart of vascular remodeling is a complex network of temporal gene expression coordinated by microRNAs, or miRNAs. Cardiovascular regeneration the generation of new functional cardiomyocytes and therapeutic angiogenesis remains a key goal in cell therapy for vascular and cardiovascular diseases. Cell differentiation elicits a complex concerto of precise miRNA expression for controlling cell fate decisions, function, and engraftment into the host. Limited improvements in animal models of ischemic disease using progenitor cell types have been shown in diseases such as chronic angina, acute MI, and heart failure. These therapies are by no means optimal. Before they can progress to the clinic, more understanding of the transcriptional control of lineage commitment is warranted. This chapter describes the role of microRNAs in vascular remodeling and in cell therapy strategies for treating ischemic diseases.
Item Type: | Book Item | ||||
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Subjects: | R Medicine > R Medicine (General) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Publisher: | Elsevier | ||||
Book Title: | MicroRNA in Regenerative Medicine | ||||
Editor: | Sen, Chandan K. | ||||
Official Date: | 2015 | ||||
Dates: |
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Page Range: | pp. 601-629 | ||||
DOI: | 10.1016/B978-0-12-405544-5.00023-X | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
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