Howard, Lynsey, Caporali, Andrea, Shantikumar, Saran and Emanueli, Costanza (2015) MicroRNAs in vascular remodeling and repair. In: Sen, Chandan K. , (ed.) MicroRNA in Regenerative Medicine. Elsevier, pp. 601-629.

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Abstract

At the heart of vascular remodeling is a complex network of temporal gene expression coordinated by microRNAs, or miRNAs. Cardiovascular regeneration the generation of new functional cardiomyocytes and therapeutic angiogenesis remains a key goal in cell therapy for vascular and cardiovascular diseases. Cell differentiation elicits a complex concerto of precise miRNA expression for controlling cell fate decisions, function, and engraftment into the host. Limited improvements in animal models of ischemic disease using progenitor cell types have been shown in diseases such as chronic angina, acute MI, and heart failure. These therapies are by no means optimal. Before they can progress to the clinic, more understanding of the transcriptional control of lineage commitment is warranted. This chapter describes the role of microRNAs in vascular remodeling and in cell therapy strategies for treating ischemic diseases.

Item Type:	Book Item
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Warwick Medical School
Publisher:	Elsevier
Book Title:	MicroRNA in Regenerative Medicine
Editor:	Sen, Chandan K.
Official Date:	2015
Dates:	Date Event 2015 Published
Page Range:	pp. 601-629
DOI:	10.1016/B978-0-12-405544-5.00023-X
Status:	Peer Reviewed
Publication Status:	Published

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