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Orthogonal riboswitches for tuneable coexpression in bacteria
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Dixon, Neil, Robinson, Christopher J., Geerlings, Torsten, Duncan, John, Drummond, Sheona P. and Micklefield, Jason (2012) Orthogonal riboswitches for tuneable coexpression in bacteria. Angewandte Chemie International Edition, 51 (15). pp. 3620-3624. doi:10.1002/anie.201109106 ISSN 1433-7851.
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Official URL: http://dx.doi.org/10.1002/anie.201109106
Abstract
Orthogonal gene control: Orthogonal riboswitches can be deployed in the same bacterial cell to independently control the coexpression of multiple genes in a dose-dependent response to distinct synthetic small molecules. This technique allows convenient access to highly dynamic expression landscapes and desirable protein stoichiometries.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QP Physiology | |||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | RNA., Riboswitches., Gene expression., RNA-protein interactions., Ligands (Biochemistry), Genetic regulation., Messenger RNA., Molecular genetics -- Methodology., Molecular genetics -- Technique. | |||||||||
| Journal or Publication Title: | Angewandte Chemie International Edition | |||||||||
| Publisher: | Wiley - V C H | |||||||||
| ISSN: | 1433-7851 | |||||||||
| Official Date: | April 2012 | |||||||||
| Dates: |
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| Volume: | 51 | |||||||||
| Number: | 15 | |||||||||
| Page Range: | pp. 3620-3624 | |||||||||
| DOI: | 10.1002/anie.201109106 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||
| RIOXX Funder/Project Grant: |
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