The Library
Effect of increased potassium intake on health : systematic review and meta-analysis
Tools
Tools
Tools
Aburto, Nancy J. , Hanson, Sara, Gutierrez, Hialy, Hooper, Lee, Elliott, Paul and Cappuccio, Francesco (2013) Effect of increased potassium intake on health : systematic review and meta-analysis. British Medical Journal, 346 . f1378. doi:10.1136/bmj.f1378 ISSN 0959-8146.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1136/bmj.f1378
Abstract
Objective
To conduct a systematic review of the literature and meta-analyses to fill the gaps in knowledge on potassium intake and health.
Data sources
Cochrane Central Register of Controlled Trials, Medline, Embase, WHO International Clinical Trials Registry Platform, Latin American and Caribbean Health Science Literature Database, and the reference lists of previous reviews.
Study selection
Randomised controlled trials and cohort studies reporting the effects of potassium intake on blood pressure, renal function, blood lipids, catecholamine concentrations, all cause mortality, cardiovascular disease, stroke, and coronary heart disease were included.
Data extraction and synthesis. Potential studies were independently screened in duplicate, and their characteristics and outcomes were extracted. When possible, meta-analysis was done to estimate the effects (mean difference or risk ratio with 95% confidence interval) of higher potassium intake by using the inverse variance method and a random effect model.
Results
22 randomised controlled trials (including 1606 participants) reporting blood pressure, blood lipids, catecholamine concentrations, and renal function and 11 cohort studies (127,038 participants) reporting all cause mortality, cardiovascular disease, stroke, or coronary heart disease in adults were included in the meta-analyses. Increased potassium intake reduced systolic blood pressure by 3.49 (95% confidence interval 1.82 to 5.15) mm Hg and diastolic blood pressure by 1.96 (0.86 to 3.06) mm Hg in adults, an effect seen in people with hypertension but not in those without hypertension. Systolic blood pressure was reduced by 7.16 (1.91 to 12.41) mm Hg when the higher potassium intake was 90-120 mmol/day, without any dose response. Increased potassium intake had no significant adverse effect on renal function, blood lipids, or catecholamine concentrations in adults. An inverse statistically significant association was seen between potassium intake and risk of incident stroke (risk ratio 0.76, 0.66 to 0.89). Associations between potassium intake and incident cardiovascular disease (risk ratio 0.88, 0.70 to 1.11) or coronary heart disease (0.96, 0.78 to 1.19) were not statistically significant. In children, three controlled trials and one cohort study suggested that increased potassium intake reduced systolic blood pressure by a non-significant 0.28 (-0.49 to 1.05) mm Hg.
Conclusions
High quality evidence shows that increased potassium intake reduces blood pressure in people with hypertension and has no adverse effect on blood lipid concentrations, catecholamine concentrations, or renal function in adults. Higher potassium intake was associated with a 24% lower risk of stroke (moderate quality evidence). These results suggest that increased potassium intake is potentially beneficial to most people without impaired renal handling of potassium for the prevention and control of elevated blood pressure and stroke.
| Item Type: | Journal Article | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
|||||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
|||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Cardiovascular system -- Diseases -- Nutritional aspects, Cardiovascular system -- Diseases -- Risk factors, Potassium -- Physiological effect | |||||||||||||||||||||
| Journal or Publication Title: | British Medical Journal | |||||||||||||||||||||
| Publisher: | BMJ Group | |||||||||||||||||||||
| ISSN: | 0959-8146 | |||||||||||||||||||||
| Official Date: | 4 April 2013 | |||||||||||||||||||||
| Dates: |
|
|||||||||||||||||||||
| Volume: | 346 | |||||||||||||||||||||
| Article Number: | f1378 | |||||||||||||||||||||
| DOI: | 10.1136/bmj.f1378 | |||||||||||||||||||||
| Status: | Not Peer Reviewed | |||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
| RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
