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Synthetic glycopolypeptides as potential inhibitory agents for dendritic cells and HIV-1 trafficking
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Huang, Jin, Zhang, Qiang, Li, Guang‐Zhao, Haddleton, David M., Wallis, Russell, Mitchell, Daniel A., Heise, Andreas and Becer, C. Remzi (2013) Synthetic glycopolypeptides as potential inhibitory agents for dendritic cells and HIV-1 trafficking. Macromolecular Rapid Communications, 34 (19). pp. 1542-1546. doi:10.1002/marc.201300439 ISSN 1022-1336.
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Official URL: http://dx.doi.org/10.1002/marc.201300439
Abstract
Multivalent binding is a key for many critical biological processes and unique recognition and specificity in binding enables many of different glycans and proteins to work in a great harmony within the human body. In this study, the binding kinetics of synthetic glycopolypeptides to the dendritic cell lectin DC-SIGN and their inhibition potential for DC-SIGN interactions with the gp120 envelope glycoprotein of HIV-1 (gp120) are investigated.
Item Type: | Journal Article | ||||||||||||||||||||||||
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Subjects: | Q Science > QR Microbiology > QR355 Virology | ||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Dendritic cells, HIV (Viruses) -- Molecular aspects, Polypeptides | ||||||||||||||||||||||||
Journal or Publication Title: | Macromolecular Rapid Communications | ||||||||||||||||||||||||
Publisher: | Wiley - V C H | ||||||||||||||||||||||||
ISSN: | 1022-1336 | ||||||||||||||||||||||||
Official Date: | October 2013 | ||||||||||||||||||||||||
Dates: |
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Volume: | 34 | ||||||||||||||||||||||||
Number: | 19 | ||||||||||||||||||||||||
Page Range: | pp. 1542-1546 | ||||||||||||||||||||||||
DOI: | 10.1002/marc.201300439 | ||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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