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Achilles tendinopathy management : a pilot randomised controlled trial comparing platelet rich plasma injection to an eccentric loading programme
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Kearney, Rebecca S., Parsons, Nicholas R. and Costa, Matthew L. (2013) Achilles tendinopathy management : a pilot randomised controlled trial comparing platelet rich plasma injection to an eccentric loading programme. Bone & Joint Research, 2 (10). pp. 227-232. doi:10.1302/2046-3758.210.2000200
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Official URL: http://dx.doi.org/ 10.1302/2046-3758.210.2000200
Abstract
OBJECTIVES:
To conduct a pilot randomised controlled trial to evaluate the feasibility of conducting a larger trial to evaluate the difference in Victorian Institute of Sports Assessment-Achilles (VISA-A) scores at six months between patients with Achilles tendinopathy treated with a platelet-rich plasma (PRP) injection compared with an eccentric loading programme.
METHODS:
Two groups of patients with mid-substance Achilles tendinopathy were randomised to receive a PRP injection or an eccentric loading programme. A total of 20 patients were randomised, with a mean age of 49 years (35 to 66). All outcome measures were recorded at baseline, six weeks, three months and six months.
RESULTS:
The mean VISA-A score for the injection group at the primary endpoint of six months was 76.0 (95% confidence interval (CI) 58.3 to 93.7) and for the exercise group was 57.4 (95% CI 38.1 to 76.7). There was no statistically significant difference between these scores (p = 0.171), which was expected from such a pilot study.
CONCLUSIONS:
This pilot study has been key to providing data to inform a larger study and shows that the methodology is feasible. Cite this article: Bone Joint Res 2013;2:227-32.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | R Medicine > RD Surgery | ||||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Achilles tendon—Wounds and injuries, Blood plasma., Tendons -- Wounds and injuries -- Healing., Musculoskeletal system -- Diseases -- Molecular aspects., Electric stimulation | ||||||||||
| Journal or Publication Title: | Bone & Joint Research | ||||||||||
| Publisher: | British Editorial Society of Bone and Joint Surgery | ||||||||||
| ISSN: | 2046-3758 | ||||||||||
| Official Date: | 17 October 2013 | ||||||||||
| Dates: |
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| Volume: | 2 | ||||||||||
| Number: | 10 | ||||||||||
| Page Range: | pp. 227-232 | ||||||||||
| DOI: | 10.1302/2046-3758.210.2000200 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access |
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