Kearney, Rebecca S., Parsons, Nicholas R. and Costa, Matthew L. (2013) Achilles tendinopathy management : a pilot randomised controlled trial comparing platelet rich plasma injection to an eccentric loading programme. Bone & Joint Research, 2 (10). pp. 227-232. doi:10.1302/2046-3758.210.2000200 ISSN 2046-3758.

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Abstract

OBJECTIVES:
To conduct a pilot randomised controlled trial to evaluate the feasibility of conducting a larger trial to evaluate the difference in Victorian Institute of Sports Assessment-Achilles (VISA-A) scores at six months between patients with Achilles tendinopathy treated with a platelet-rich plasma (PRP) injection compared with an eccentric loading programme.
METHODS:
Two groups of patients with mid-substance Achilles tendinopathy were randomised to receive a PRP injection or an eccentric loading programme. A total of 20 patients were randomised, with a mean age of 49 years (35 to 66). All outcome measures were recorded at baseline, six weeks, three months and six months.
RESULTS:
The mean VISA-A score for the injection group at the primary endpoint of six months was 76.0 (95% confidence interval (CI) 58.3 to 93.7) and for the exercise group was 57.4 (95% CI 38.1 to 76.7). There was no statistically significant difference between these scores (p = 0.171), which was expected from such a pilot study.
CONCLUSIONS:
This pilot study has been key to providing data to inform a larger study and shows that the methodology is feasible. Cite this article: Bone Joint Res 2013;2:227-32.

Item Type:	Journal Article
Subjects:	R Medicine > RD Surgery
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Achilles tendon—Wounds and injuries, Blood plasma., Tendons -- Wounds and injuries -- Healing., Musculoskeletal system -- Diseases -- Molecular aspects., Electric stimulation
Journal or Publication Title:	Bone & Joint Research
Publisher:	British Editorial Society of Bone and Joint Surgery
ISSN:	2046-3758
Official Date:	17 October 2013
Dates:	Date Event 17 October 2013 Published 1 October 2013 Available 30 August 2013 Accepted 28 May 2013 Submitted
Volume:	2
Number:	10
Page Range:	pp. 227-232
DOI:	10.1302/2046-3758.210.2000200
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)

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