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Achilles tendinopathy management : a pilot randomised controlled trial comparing platelet rich plasma injection to an eccentric loading programme

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Kearney, Rebecca S., Parsons, Nicholas R. and Costa, Matthew L. (2013) Achilles tendinopathy management : a pilot randomised controlled trial comparing platelet rich plasma injection to an eccentric loading programme. Bone & Joint Research, 2 (10). pp. 227-232. doi:10.1302/2046-3758.210.2000200

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Official URL: http://dx.doi.org/ 10.1302/2046-3758.210.2000200

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Abstract

OBJECTIVES:
To conduct a pilot randomised controlled trial to evaluate the feasibility of conducting a larger trial to evaluate the difference in Victorian Institute of Sports Assessment-Achilles (VISA-A) scores at six months between patients with Achilles tendinopathy treated with a platelet-rich plasma (PRP) injection compared with an eccentric loading programme.
METHODS:
Two groups of patients with mid-substance Achilles tendinopathy were randomised to receive a PRP injection or an eccentric loading programme. A total of 20 patients were randomised, with a mean age of 49 years (35 to 66). All outcome measures were recorded at baseline, six weeks, three months and six months.
RESULTS:
The mean VISA-A score for the injection group at the primary endpoint of six months was 76.0 (95% confidence interval (CI) 58.3 to 93.7) and for the exercise group was 57.4 (95% CI 38.1 to 76.7). There was no statistically significant difference between these scores (p = 0.171), which was expected from such a pilot study.
CONCLUSIONS:
This pilot study has been key to providing data to inform a larger study and shows that the methodology is feasible. Cite this article: Bone Joint Res 2013;2:227-32.

Item Type: Journal Article
Subjects: R Medicine > RD Surgery
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Achilles tendon—Wounds and injuries, Blood plasma., Tendons -- Wounds and injuries -- Healing., Musculoskeletal system -- Diseases -- Molecular aspects., Electric stimulation
Journal or Publication Title: Bone & Joint Research
Publisher: British Editorial Society of Bone and Joint Surgery
ISSN: 2046-3758
Official Date: 17 October 2013
Dates:
DateEvent
17 October 2013Published
1 October 2013Available
30 August 2013Accepted
28 May 2013Submitted
Volume: 2
Number: 10
Page Range: pp. 227-232
DOI: 10.1302/2046-3758.210.2000200
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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