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Aspirin and heparin as adjuvants during IVF do not improve live birth rates in unexplained implantation failure.
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Akhtar, Muhammad A., Eljabu, Hanan, Hopkisson, James, Raine-Fenning, Nick, Quenby, Siobhan and Jayaprakasan, Kannamannadiar (2013) Aspirin and heparin as adjuvants during IVF do not improve live birth rates in unexplained implantation failure. Reproductive Biomedicine Online, 26 (6). pp. 586-594. S1472-6483(13)00071-0. doi:10.1016/j.rbmo.2013.02.007
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Official URL: http://dx.doi.org/10.1016/j.rbmo.2013.02.007
Abstract
This study tested the hypothesis that using aspirin and/or heparin as adjuvants in IVF improves the treatment outcome. This retrospective cohort-control study recruited 234 consecutive subjects aged ≤ 44 years who had previously had one or more unsuccessful IVF cycle. All underwent IVF using conventional protocols. The study group received aspirin and/or heparin post embryo transfer until the day of pregnancy test or until 12 weeks of pregnancy. The control group did not receive adjuvant treatment. The outcome measures were live birth, clinical pregnancy and miscarriage rates. The outcomes were compared by chi-squared test and relative-risk analysis. Analysis was performed in 206 subjects. There was no statistically significant difference in the live birth rate (35.0%, 36/103 versus 47.6%, 49/103), clinical pregnancy rate (40.8%, 42/103 versus 53.4%, 55/103) and miscarriage rate (14.3%, 6/42 versus 10.9%, 6/55) between the study group and the control group. The data in this study show that low-dose aspirin and/or heparin as adjuvant therapies during IVF do not improve live birth rates in an unselected group of subfertile women who have previously had one or more unexplained implantation failure following IVF.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | Q Science > QM Human anatomy Q Science > QP Physiology R Medicine > RG Gynecology and obstetrics R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > ( - July 2016) Health Education Hub Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Aspirin , Endometrium, Heparin, Human embryo--Transplantation, Fertilization in vitro, Pregnancy--Complications | ||||||||||
| Journal or Publication Title: | Reproductive Biomedicine Online | ||||||||||
| Publisher: | Elsevier Ltd | ||||||||||
| ISSN: | 1472-6483 | ||||||||||
| Official Date: | September 2013 | ||||||||||
| Dates: |
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| Volume: | 26 | ||||||||||
| Number: | 6 | ||||||||||
| Page Range: | pp. 586-594 | ||||||||||
| Article Number: | S1472-6483(13)00071-0 | ||||||||||
| DOI: | 10.1016/j.rbmo.2013.02.007 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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