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Aspirin and heparin as adjuvants during IVF do not improve live birth rates in unexplained implantation failure.

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Akhtar, Muhammad A., Eljabu, Hanan, Hopkisson, James, Raine-Fenning, Nick, Quenby, Siobhan and Jayaprakasan, Kannamannadiar (2013) Aspirin and heparin as adjuvants during IVF do not improve live birth rates in unexplained implantation failure. Reproductive Biomedicine Online, 26 (6). pp. 586-594. S1472-6483(13)00071-0. doi:10.1016/j.rbmo.2013.02.007

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Official URL: http://dx.doi.org/10.1016/j.rbmo.2013.02.007

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Abstract

This study tested the hypothesis that using aspirin and/or heparin as adjuvants in IVF improves the treatment outcome. This retrospective cohort-control study recruited 234 consecutive subjects aged ≤ 44 years who had previously had one or more unsuccessful IVF cycle. All underwent IVF using conventional protocols. The study group received aspirin and/or heparin post embryo transfer until the day of pregnancy test or until 12 weeks of pregnancy. The control group did not receive adjuvant treatment. The outcome measures were live birth, clinical pregnancy and miscarriage rates. The outcomes were compared by chi-squared test and relative-risk analysis. Analysis was performed in 206 subjects. There was no statistically significant difference in the live birth rate (35.0%, 36/103 versus 47.6%, 49/103), clinical pregnancy rate (40.8%, 42/103 versus 53.4%, 55/103) and miscarriage rate (14.3%, 6/42 versus 10.9%, 6/55) between the study group and the control group. The data in this study show that low-dose aspirin and/or heparin as adjuvant therapies during IVF do not improve live birth rates in an unselected group of subfertile women who have previously had one or more unexplained implantation failure following IVF.

Item Type: Journal Article
Subjects: Q Science > QM Human anatomy
Q Science > QP Physiology
R Medicine > RG Gynecology and obstetrics
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine > Warwick Medical School > ( - July 2016) Health Education Hub
Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016)
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Aspirin , Endometrium, Heparin, Human embryo--Transplantation, Fertilization in vitro, Pregnancy--Complications
Journal or Publication Title: Reproductive Biomedicine Online
Publisher: Elsevier Ltd
ISSN: 1472-6483
Official Date: September 2013
Dates:
DateEvent
September 2013Published
20 February 2013Available
7 February 2013Accepted
11 October 2012Submitted
Volume: 26
Number: 6
Page Range: pp. 586-594
Article Number: S1472-6483(13)00071-0
DOI: 10.1016/j.rbmo.2013.02.007
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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