Salokangas, R. K. R., Nieman, D. H., Heinimaa, M., Svirskis, T., Luutonen, S., From, T., von Reventlow, H. G., Juckel, G., Linszen, D., Dingemans, P., Birchwood, M. J., Patterson, Paul, Schultze-Lutter, F., Klosterkotter, J. and Ruhrmann, S. (2013) Psychosocial outcome in patients at clinical high risk of psychosis : a prospective follow-up. Social Psychiatry and Psychiatric Epidemiology, 48 (2). pp. 303-311. doi:10.1007/s00127-012-0545-2 ISSN 0933-7954.

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Abstract

PURPOSE:
In patients at clinical high risk (CHR) of psychosis, transition to psychosis has been the focus of recent studies. Their broader outcome has received less attention. We studied psychosocial state and outcome in CHR patients.
METHODS:
In the European Prediction of Psychosis Study, 244 young help-seeking CHR patients were assessed with the Strauss and Carpenter Prognostic Scale (SCPS) at baseline, and 149 (61.1%) of them were assessed for the second time at the 18-month follow-up. The followed patients were classified into poor and good outcome groups.
RESULTS:
Female gender, ever-married/cohabitating relationship, and good working/studying situation were associated with good baseline SCPS scores. During follow-up, patients' SCPS scores improved significantly. Good follow-up SCPS scores were predicted by higher level of education, good working/studying status at baseline, and white ethnicity. One-third of the followed CHR patients had poor global outcome. Poor working/studying situation and lower level of education were associated with poor global outcome. Transition to psychosis was associated with baseline, but not with follow-up SCPS scores or with global outcome.
CONCLUSION:
The majority of CHR patients experience good short-term recovery, but one-third have poor psychosocial outcome. Good working situation is the major indicator of good outcome, while low level of education and non-white ethnicity seem to be associated with poor outcome. Transition to psychosis has little effect on psychosocial outcome in CHR patients. In treating CHR patients, clinicians should focus their attention on a broader outcome, and not only on preventing transition to psychosis.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Psychoses , Psychoses -- Diagnosis
Journal or Publication Title:	Social Psychiatry and Psychiatric Epidemiology
Publisher:	Dr. Dietrich Steinkopff Verlag
ISSN:	0933-7954
Official Date:	February 2013
Dates:	Date Event February 2013 Published 15 July 2012 Available 18 June 2012 Accepted 30 March 2012 Submitted
Volume:	48
Number:	2
Page Range:	pp. 303-311
DOI:	10.1007/s00127-012-0545-2
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Universität zu Köln. Medizinische Fakultät, Social Insurance Institution of Finland
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID QLG4-CT-2001-01081 Fifth Framework Programme http://dx.doi.org/10.13039/100011104 UNSPECIFIED National Institute for Health Research http://dx.doi.org/10.13039/501100000272

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