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The Strauss and Carpenter Prognostic Scale in subjects clinically at high risk of psychosis

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Nieman, D. H., Velthorst, E., Becker, H. E., de Haa, L., Dingemans, P. M., Linszen, D. H., Birchwood, M. J., Patterson, Paul, Salokangas, R. K. R., Heinimaa, M., Heinz, Andreas, Juckel, G., von Reventlow, H. G., Morrison, A. P., Schultze-Lutter, F., Klosterkotter, J. and Ruhrmann, S. (2013) The Strauss and Carpenter Prognostic Scale in subjects clinically at high risk of psychosis. Acta Psychiatrica Scandinavica, 127 (1). pp. 53-61. ISSN 0001-690X.

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Official URL: http://dx.doi.org/10.1111/j.1600-0447.2012.01899.x

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Abstract

Objective:
To investigate the predictive value of the Strauss and Carpenter Prognostic Scale (SCPS) for transition to a first psychotic episode in subjects clinically at high risk (CHR) of psychosis.
Method:
Two hundred and forty-four CHR subjects participating in the European Prediction of Psychosis Study were assessed with the SCPS, an instrument that has been shown to predict outcome in patients with schizophrenia reliably.
Results:
At 18-month follow-up, 37 participants had made the transition to psychosis. The SCPS total score was predictive of a first psychotic episode (P < 0.0001). SCPS items that remained as independent predictors in the Cox proportional hazard model were as follows: most usual quality of useful work in the past year (P = 0.006), quality of social relations (P = 0.006), presence of thought disorder, delusions or hallucinations in the past year (P = 0.001) and reported severity of subjective distress in past month (P = 0.003).
Conclusion:
The SCPS could make a valuable contribution to a more accurate prediction of psychosis in CHR subjects as a second-step tool. SCPS items assessing quality of useful work and social relations, positive symptoms and subjective distress have predictive value for transition. Further research should focus on investigating whether targeted early interventions directed at the predictive domains may improve outcomes.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Psychoses, Psychoses -- Prognosis, Mental illness -- Diagnosis, Psychoses -- Early detection
Journal or Publication Title: Acta Psychiatrica Scandinavica
Publisher: Wiley-Blackwell Publishing, Inc.
ISSN: 0001-690X
Official Date: January 2013
Dates:
DateEvent
January 2013Published
7 July 2012Available
Volume: 127
Number: 1
Page Range: pp. 53-61
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Collaborations for Leadership in Applied Health Research and Care (CLAHRC)
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
QLG4‐CT‐2001‐01081Fifth Framework Programmehttp://dx.doi.org/10.13039/100011104
2630.0001ZonMwhttp://dx.doi.org/10.13039/501100001826
12‐26‐2006Kelahttp://dx.doi.org/10.13039/501100002327
KΓΆln Fortune ProgramCenter for Molecular Medicine Cologne, University of Colognehttp://dx.doi.org/10.13039/501100009983
UNSPECIFIED[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272

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