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Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection : results from a large, consecutive Norwegian series
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Merok, M. A., Ahlquist, T. C., Royrvik, E. C., Tufteland, K. F., Hektoen, M., Sjo, O. H., Mala, T., Svindland, A., Lothe, R. A. and Nesbakken, A. (2013) Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection : results from a large, consecutive Norwegian series. Annals of Oncology, 24 (5). pp. 1274-1282. doi:10.1093/annonc/mds614
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Official URL: http://dx.doi.org/10.1093/annonc/mds614
Abstract
BACKGROUND:
Microsatellite instability (MSI) was suggested as a marker for good prognosis in colorectal cancer in 1993 and a systematic review from 2005 and a meta-analysis from 2010 support the initial observation. We here assess the prognostic impact and prevalence of MSI in different stages in a consecutive, population-based series from a single hospital in Oslo, Norway.
PATIENTS AND METHODS:
Of 1274 patients, 952 underwent major resection of which 805 were included in analyses of MSI prevalence and 613 with complete resection in analyses of outcome. Formalin-fixed tumor tissue was used for PCR-based MSI analyses.
RESULTS:
The overall prevalence of MSI was 14%, highest in females (19%) and in proximal colon cancer (29%). Five-year relapse-free survival (5-year RFS) was 67% and 55% (P = 0.030) in patients with MSI and MSS tumors, respectively, with the hazard ratio (HR) equal to 1.60 (P = 0.045) in multivariate analysis. The improved outcome was confined to stage II patients who had 5-year RFS of 74% and 56% respectively (P = 0.010), HR = 2.02 (P = 0.040). Examination of 12 or more lymph nodes was significantly associated with proximal tumor location (P < 0.001).
CONCLUSIONS:
MSI has an independent positive prognostic impact on stage II colorectal cancer patients after complete resection.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Colon (Anatomy) -- Cancer -- Norway, Microsatellites (Genetics) -- Research | ||||||||||
| Journal or Publication Title: | Annals of Oncology | ||||||||||
| Publisher: | Oxford University Press | ||||||||||
| ISSN: | 0923-7534 | ||||||||||
| Official Date: | May 2013 | ||||||||||
| Dates: |
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| Volume: | 24 | ||||||||||
| Number: | 5 | ||||||||||
| Page Range: | pp. 1274-1282 | ||||||||||
| DOI: | 10.1093/annonc/mds614 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access | ||||||||||
| Funder: | Norske kreftforening‏ [Norwegian Cancer Society] | ||||||||||
| Grant number: | RAL: grants PR-2006-0442 and 2008-0151 |
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