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Prediction of acute antibody mediated rejection in antibody incompatible renal transplantation using machine learning for wide data
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Shaikhina, Torgyn, Khovanova, N. A., Daga, Sunil, Krishnan, Nithya, Lowe, David Philip, Mitchell, Daniel A., Briggs, David and Higgins, Rob (2015) Prediction of acute antibody mediated rejection in antibody incompatible renal transplantation using machine learning for wide data. In: 2015 American Transplant Congress, Philadelphia, USA, 2 - 6 May 2015. Published in: American Journal Transplant, 15 (Supplement 3). p. 1364.
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Official URL: http://www.atcmeetingabstracts.com/abstract/predic...
Abstract
The dynamic field of renal transplantation is characterised by limited access to data, the high cost of equipment and underlying complexity of immunological responses to transplants. Traditional clinical studies often fail to predict the postoperative outcome as they utilize standard statistical analysis requiring large number of participants. An alternative approach, combining traditional statistical tools with the development and application of machine learning algorithms, can open new perspectives for preoperative risk assessment and provide access to safe transplantation for many currently untranslatable patients. Our study demonstrates a novel data-driven approach based on classification decision trees (DTs) for prediction of acute antibody mediated rejection in the early post-transplant period after HLA-antibody incompatible transplantation. The available clinical dataset featured 15 potential predictor variables including pre-treatment DSA IgG subclass levels across 80 observation samples, out of which 46 belonged to rejector group and 34 represented non-rejector controls.
Item Type: | Conference Item (Other) | ||||
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Subjects: | R Medicine > RD Surgery | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
Library of Congress Subject Headings (LCSH): | Kidneys -- Transplantation -- Risk factors -- Statistics, Graft rejection | ||||
Journal or Publication Title: | American Journal Transplant | ||||
Official Date: | 2015 | ||||
Dates: |
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Volume: | 15 | ||||
Number: | Supplement 3 | ||||
Page Range: | p. 1364 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Conference Paper Type: | Other | ||||
Title of Event: | 2015 American Transplant Congress | ||||
Type of Event: | Other | ||||
Location of Event: | Philadelphia, USA | ||||
Date(s) of Event: | 2 - 6 May 2015 | ||||
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