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Genetically engineered light sensors for control of bacterial gene expression
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Camsund, Daniel, Lindblad, Peter and Jaramillo, Alfonso (2011) Genetically engineered light sensors for control of bacterial gene expression. Biotechnology Journal, 6 (7). pp. 826-836. doi:10.1002/biot.201100091 ISSN 1860-6768.
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Official URL: http://dx.doi.org/10.1002/biot.201100091
Abstract
Light of different wavelengths can serve as a transient, noninvasive means of regulating gene expression for biotechnological purposes. Implementation of advanced gene regulatory circuits will require orthogonal transcriptional systems that can be simultaneously controlled and that can produce several different control states. Fully genetically encoded light sensors take advantage of the favorable characteristics of light, do not need the supplementation of any chemical inducers or co-factors, and have been demonstrated to control gene expression in Escherichia coli. Herein, we review engineered light-sensor systems with potential for in vivo regulation of gene expression in bacteria, and highlight different means of extending the range of available light input and transcriptional output signals. Furthermore, we discuss advances in multiplexing different light sensors for achieving multichromatic control of gene expression and indicate developments that could facilitate the construction of efficient systems for light-regulated, multistate control of gene expression.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QH Natural history Q Science > QP Physiology T Technology > TP Chemical technology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Library of Congress Subject Headings (LCSH): | Photoreceptors, Protein engineering, Synthetic biology | ||||||
Journal or Publication Title: | Biotechnology Journal | ||||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||
ISSN: | 1860-6768 | ||||||
Official Date: | July 2011 | ||||||
Dates: |
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Volume: | 6 | ||||||
Number: | 7 | ||||||
Number of Pages: | 11 | ||||||
Page Range: | pp. 826-836 | ||||||
DOI: | 10.1002/biot.201100091 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
Funder: | Sweden. Energimyndigheten [Swedish Energy Agency], Knut and Alice Wallenberg Foundation, Seventh Framework Programme (European Commission) (FP7), Sixth Framework Programme (European Commission) (FP6), Genopole (Firm), Fondation pour la recherche médicale | ||||||
Grant number: | 212508 (FP7), 043340 (FP6), ICT-043338 (FP7), ICT-265505 (FP7), |
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