Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Immunity and early pregnancy events : are endocannabinoids the missing link?

Tools
- Tools
+ Tools

Bambang, K. N., Lambert, David, Lam, P. M. W., Quenby, Siobhan, Maccarrone, M. and Konje, J. C. (2012) Immunity and early pregnancy events : are endocannabinoids the missing link? Journal of Reproductive Immunology, 96 (1-2). pp. 8-18. doi:10.1016/j.jri.2012.10.003

Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1016/j.jri.2012.10.003

Request Changes to record.

Abstract

The success of pregnancy is dependent on a number of different cell types and signalling pathways, including immune cells which play a vital role in implantation. Immune cells express transcripts for all of the components of the endocannabinoid system, but the role of this system in the function of reproductive tract immune cells is still unclear. In this review, we present the hypothesis that the endocannabinoid signalling system is central to an endocannabinoid-immune-reproductive axis, and that it acts as the link via which immune cells exert their vital influence on implantation and foetal tolerance. Pubmed and Web of Science databases were searched for studies published since 1975 which explore the interaction between the endocannabinoid system and the immune system, the endocannabinoid system in pregnancy as well as the role of immune cells in pregnancy. There is evidence that the endocannabinoid system has established effects in several immune cell lineages including NK cells and T lymphocytes known to be crucial in the development of normal pregnancy. These effects include regulation of cytokine production, chemotaxis and proliferation. The immune system plays a critical role in placental development and foetal tolerance, achieving this through a large number of cytokines and chemokines. We conclude that there are intricate molecular interactions involved in the success of early pregnancy and that the endocannabinoid system, potentially interacting with the immune system, is a key contributor to these events.

Item Type: Journal Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016)
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Pregnancy, Generative organs, Female, Fertility, Human, Immunity, Systematic reviews (Medical research)
Journal or Publication Title: Journal of Reproductive Immunology
Publisher: Elsevier Ireland Ltd
ISSN: 0165-0378
Official Date: December 2012
Dates:
DateEvent
December 2012Published
20 November 2012Available
11 October 2012Accepted
3 May 2012Submitted
Volume: 96
Number: 1-2
Page Range: pp. 8-18
DOI: 10.1016/j.jri.2012.10.003
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us