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Use of concave corners in the segmentation of embryological datasets

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Rafferty, K., Drury, Sarah L., Hartshorne, Geraldine M. and Czanner, Silvester (2012) Use of concave corners in the segmentation of embryological datasets. Review of Bioinformatics and Biometrics, 1 (1). pp. 1-8.

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Official URL: http://www.seipub.org/rbb/paperInfo.aspx?ID=2338

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Abstract

Embryologists require identifiable factors when analysing embryos grown in‐vitro that can better predict an embryos
successful development in the uterus. It has been proposed that the volume of various embryo features, such as
blastomeres, within a developing of embryo could be used as an indicator of viability. An initial interface has been
developed using existing image processing tools to segment z‐stacks produced via confocal microscopy and create a set of volumes for analysis. A further addition to these tools was developed with the intent of improving the accuracy of the segmentation process; specifically, in identifying individual blastomeres whose proximity to neighbouring blastomeres resulted in the false identification of a single segment. A method has been proposed that uses a contour produced by an earlier segmentation procedure and identifies concave regions along the contour. These are interpreted as probable indicators of the location of boundaries between different blastomeres. By using points along the contour in these concave regions we attempt to extrapolate the boundaries between blastomeres.

Item Type: Journal Article
Subjects: Q Science > QL Zoology
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016)
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Embryology
Journal or Publication Title: Review of Bioinformatics and Biometrics
Publisher: Science and Engineering Publishing Company
ISSN: 2326-5825
Official Date: 27 December 2012
Dates:
DateEvent
27 December 2012Published
Volume: 1
Number: 1
Number of Pages: 8
Page Range: pp. 1-8
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: University Hospitals Coventry and Warwickshire NHS Trust, Warwick Teaching and Learning Enhancement Fund, University of Warwick. Institute of Advanced Study (IAS)
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