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Use of concave corners in the segmentation of embryological datasets
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Rafferty, K., Drury, Sarah L., Hartshorne, Geraldine M. and Czanner, Silvester (2012) Use of concave corners in the segmentation of embryological datasets. Review of Bioinformatics and Biometrics, 1 (1). pp. 1-8. ISSN 2326-5825.
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Official URL: http://www.seipub.org/rbb/paperInfo.aspx?ID=2338
Abstract
Embryologists require identifiable factors when analysing embryos grown in‐vitro that can better predict an embryos
successful development in the uterus. It has been proposed that the volume of various embryo features, such as
blastomeres, within a developing of embryo could be used as an indicator of viability. An initial interface has been
developed using existing image processing tools to segment z‐stacks produced via confocal microscopy and create a set of volumes for analysis. A further addition to these tools was developed with the intent of improving the accuracy of the segmentation process; specifically, in identifying individual blastomeres whose proximity to neighbouring blastomeres resulted in the false identification of a single segment. A method has been proposed that uses a contour produced by an earlier segmentation procedure and identifies concave regions along the contour. These are interpreted as probable indicators of the location of boundaries between different blastomeres. By using points along the contour in these concave regions we attempt to extrapolate the boundaries between blastomeres.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QL Zoology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Embryology | ||||
Journal or Publication Title: | Review of Bioinformatics and Biometrics | ||||
Publisher: | Science and Engineering Publishing Company | ||||
ISSN: | 2326-5825 | ||||
Official Date: | 27 December 2012 | ||||
Dates: |
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Volume: | 1 | ||||
Number: | 1 | ||||
Number of Pages: | 8 | ||||
Page Range: | pp. 1-8 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | University Hospitals Coventry and Warwickshire NHS Trust, Warwick Teaching and Learning Enhancement Fund, University of Warwick. Institute of Advanced Study (IAS) | ||||
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