The Library
Redefining the components of central CO2 chemosensitivity : towards a better understanding of mechanism
Tools
Tools
Tools
Huckstepp, Robert T. R. and Dale, Nicholas (2011) Redefining the components of central CO2 chemosensitivity : towards a better understanding of mechanism. The Journal of Physiology, 589 (23). pp. 5561-5579. doi:10.1113/jphysiol.2011.214759
Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1113/jphysiol.2011.214759
Abstract
The field of CO2 chemosensitivity has developed considerably in recent years. There has been a mounting number of competing nuclei proposed as chemosensitive along with an ever increasing list of potential chemosensory transducing molecules. Is it really possible that all of these areas and candidate molecules are involved in the detection of chemosensory stimuli? How do we discriminate rigorously between molecules that are chemosensory transducers at the head of a physiological reflex versus those that just happen to display sensitivity to a chemosensory stimulus? Equally, how do we differentiate between nuclei that have a primary chemosensory function, versus those that are relays in the pathway? We have approached these questions by proposing rigorous definitions for the different components of the chemosensory reflex, going from the salient molecules and ions, through the components of transduction to the identity of chemosensitive cells and chemosensitive nuclei. Our definitions include practical and rigorous experimental tests that can be used to establish the identity of these components. We begin by describing the need for central CO2 chemosensitivity and the problems that the field has faced. By comparing chemosensory mechanisms to those in the visual system we suggest stricter definitions for the components of the chemosensory pathway. We then, considering these definitions, re-evaluate current knowledge of chemosensory transduction, and propose the ‘multiple salient signal hypothesis’ as a framework for understanding the multiplicity of transduction mechanisms and brain areas seemingly involved in chemosensitivity.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history | ||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Carbon dioxide -- Physiological effect | ||||||
| Journal or Publication Title: | The Journal of Physiology | ||||||
| Publisher: | Blackwell | ||||||
| ISSN: | 0022-3751 | ||||||
| Official Date: | December 2011 | ||||||
| Dates: |
|
||||||
| Volume: | 589 | ||||||
| Number: | 23 | ||||||
| Number of Pages: | 19 | ||||||
| Page Range: | pp. 5561-5579 | ||||||
| DOI: | 10.1113/jphysiol.2011.214759 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Medical Research Council (Great Britain) (MRC) |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
