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Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe : a TBNET consensus statement
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(2014) Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe : a TBNET consensus statement. European Respiratory Journal, 44 ( 1). pp. 23-63. doi:10.1183/09031936.00188313 ISSN 0903-1936.
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Official URL: http://dx.doi.org/10.1183/09031936.00188313
Abstract
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) substantially challenges TB control, especially in the European Region of the World Health Organization, where the highest prevalence of MDR/XDR cases is reported. The current management of patients with MDR/XDR-TB is extremely complex for medical, social and public health systems. The treatment with currently available anti-TB therapies to achieve relapse-free cure is long and undermined by a high frequency of adverse drug events, suboptimal treatment adherence, high costs and low treatment success rates. Availability of optimal management for patients with MDR/XDR-TB is limited even in the European Region. In the absence of a preventive vaccine, more effective diagnostic tools and novel therapeutic interventions the control of MDR/XDR-TB will be extremely difficult. Despite recent scientific advances in MDR/XDR-TB care, decisions for the management of patients with MDR/XDR-TB and their contacts often rely on expert opinions, rather than on clinical evidence. This document summarises the current knowledge on the prevention, diagnosis and treatment of adults and children with MDR/XDR-TB and their contacts, and provides expert consensus recommendations on questions where scientific evidence is still lacking.
Item Type: | Journal Article | ||||||||||
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Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Multidrug-resistant tuberculosis|--Diagnosis, Multidrug-resistant tuberculosis--Epidemiology, Drug resistance in microorganisms, Antitubercular agents, Tuberculosis--Prevention | ||||||||||
Journal or Publication Title: | European Respiratory Journal | ||||||||||
Publisher: | European Respiratory Society | ||||||||||
ISSN: | 0903-1936 | ||||||||||
Official Date: | July 2014 | ||||||||||
Dates: |
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Volume: | 44 | ||||||||||
Number: | 1 | ||||||||||
Page Range: | pp. 23-63 | ||||||||||
DOI: | 10.1183/09031936.00188313 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 30 December 2015 | ||||||||||
Date of first compliant Open Access: | 30 December 2015 | ||||||||||
Funder: | German CentrE for Infection Research (DZIF), Federal Ministry of Education and Research (Germany), Medical Research Council (Great Britain) (MRC), National Institute for Medical Research (NIMR), National Institute for Health Research (Great Britain) (NIHR), Seventh Framework Programme (European Commission) (FP7) |
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