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Chemical modification of multiwalled carbon nanotube with a bifunctional caged ligand for radioactive labelling

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Ormsby, Ross W., McNally, Tony, Mitchell, Christina A., Musumeci, Anthony, Schiller, Tara L., Halley, Peter J., Gahan, Lawrence, Martin, Darren J., Smith, Suzanne V. and Dunne, Nicholas J. (2014) Chemical modification of multiwalled carbon nanotube with a bifunctional caged ligand for radioactive labelling. Acta Materialia, 64 . pp. 54-61. doi:10.1016/j.actamat.2013.10.047

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Official URL: http://dx.doi.org/10.1016/j.actamat.2013.10.047

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Abstract

Carboxyl-functionalized multiwalled carbon nanotubes (MWCNTs) have been successfully radiolabelled with cobalt-57 (57Co) (T1/2 = 270 days) via the attachment of the bifunctional caged ligand MeAMN3S3sar. In this study MeAMN3S3sar has been synthesized and coupled to MWCNTs to form the conjugate MWCNT–MeAMN3S3sar. Synthesis was confirmed with nuclear magnetic resonance. X-ray photoelectron spectroscopy (XPS) confirmed the conjugation. Non-radioactive labelling of this conjugate was completed with Cu(II) ions to confirm the stability of the MeAMN3S3sar after coupling with the MWCNTs. The complexation of the Cu(II) was also confirmed with XPS. Transmission electron microscopy was used to demonstrate that the coupling reaction had a negligible effect on the size and shape of the MWCNTs. Radiolabelling of the MWCNT–MeAMN3S3sar conjugate and pristine (untreated) MWCNTs (non-specific) with the gamma-emitting radioactive isotope 57Co were compared. The radiolabelling efficiency of the MWCNT–MeAMN3S3sar conjugate was significantly higher (95% vs. 0.1%) (P ⩽ 0.001) than for the unconjugated pristine MWCNTs. This will allow for the potential tracking of nanoparticle movement in vitro and in vivo.

Item Type: Journal Article
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
Library of Congress Subject Headings (LCSH): Carbon nanotubes, Radiolabeling
Journal or Publication Title: Acta Materialia
Publisher: Pergamon-Elsevier Science Ltd
ISSN: 1359-6454
Official Date: February 2014
Dates:
DateEvent
February 2014Published
18 December 2013Available
23 October 2013Accepted
23 July 2013Submitted
Volume: 64
Number of Pages: 9
Page Range: pp. 54-61
DOI: 10.1016/j.actamat.2013.10.047
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Northern Ireland. Department of Employment and Learning

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