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“Isothermal” LCST transitions triggered by bioreduction of single polymer end-groups
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Summers, Matthew J., Phillips, Daniel J. and Gibson, Matthew I. (2013) “Isothermal” LCST transitions triggered by bioreduction of single polymer end-groups. Chemical Communications, 49 (39). pp. 4223-4225. doi:10.1039/c2cc34236g ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/C2CC34236G
Abstract
The α-termini of RAFT-derived thermoresponsive polymers were functionalised via thiol exchange with pyridyl disulfide. Addition of hydrophilic end-groups dramatically increased the observed cloud point of the polymers, without changing the composition of the main chain. Selective cleavage of the disulfide-linked end-groups was observed under conditions intended to mimic intracellular glutathione concentration. This allowed the thermoresponsive behaviour to be ‘switched on’ without the need for a temperature stimulus – an ‘isothermal’ switch.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry T Technology > TA Engineering (General). Civil engineering (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Thermoresponsive polymers, Materials science | ||||
Journal or Publication Title: | Chemical Communications | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1359-7345 | ||||
Official Date: | 2013 | ||||
Dates: |
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Volume: | 49 | ||||
Number: | 39 | ||||
Page Range: | pp. 4223-4225 | ||||
DOI: | 10.1039/c2cc34236g | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Birmingham Science City, Higher Education Funding Council for England (HEFCE), University of Warwick Postgraduate Research Scholarship |
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