The Library
Synthesis and characterisation of glucose-functional glycopolymers and gold nanoparticles : study of their potential interactions with ovine red blood cells
Tools
Tools
Tools
Wilkinson, Laura, Phillips, Daniel J., Deller, Robert C., Davies, Gemma L. and Gibson, Matthew I. (2014) Synthesis and characterisation of glucose-functional glycopolymers and gold nanoparticles : study of their potential interactions with ovine red blood cells. Carbohydrate research, 405 . pp. 47-54. doi:10.1016/j.carres.2014.09.009 ISSN 1873-426X.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.carres.2014.09.009
Abstract
Carbohydrate–protein interactions can assist with the targeting of polymer- and nano-delivery systems. However, some potential protein targets are not specific to a single cell type, resulting in reductions in their efficacy due to undesirable non-specific cellular interactions. The glucose transporter 1 (GLUT-1) is expressed to different extents on most cells in the vasculature, including human red blood cells and on cancerous tissue. Glycosylated nanomaterials bearing glucose (or related) carbohydrates, therefore, could potentially undergo unwanted interactions with these transporters, which may compromise the nanomaterial function or lead to cell agglutination, for example. Here, RAFT polymerisation is employed to obtain well-defined glucose-functional glycopolymers as well as glycosylated gold nanoparticles. Agglutination and binding assays did not reveal any significant binding to ovine red blood cells, nor any haemolysis. These data suggest that gluco-functional nanomaterials are compatible with blood, and their lack of undesirable interactions highlights their potential for delivery and imaging applications.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
| Library of Congress Subject Headings (LCSH): | Glycomics, Nanoparticles, Biocompatibility, Blood, Gold | ||||||||
| Journal or Publication Title: | Carbohydrate research | ||||||||
| Publisher: | Pergamon-Elsevier Science Ltd. | ||||||||
| ISSN: | 1873-426X | ||||||||
| Official Date: | March 2014 | ||||||||
| Dates: |
|
||||||||
| Volume: | 405 | ||||||||
| Page Range: | pp. 47-54 | ||||||||
| DOI: | 10.1016/j.carres.2014.09.009 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Funder: | Advantage West Midlands (AWM), European Regional Development Fund (ERDF), University of Warwick Postgraduate Research Scholarship, University of Warwick. Institute of Advanced Study (IAS), Royal Society (Great Britain), University of Warwick. Medical And Life Sciences Research Fund, General Charities of the City of Coventry (GCCC) |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
