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Using molecular rotors to probe gelation

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Raeburn, Jaclyn, Chen, Lin, Awhida, Salmah, Deller, Robert C., Vatish, Manu, Gibson, Matthew I. and Adams, Dave J. (2015) Using molecular rotors to probe gelation. Soft matter, 11 (18). pp. 3706-3713. doi:10.1039/c5sm00456j ISSN 1744-683X.

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Official URL: http://dx.doi.org/10.1039/C5SM00456J

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Abstract

A series of fluorescent probes, including a number of molecular rotors, have been used to follow the self-assembly of dipeptide-based low molecular weight gelators. We show that these probes can be used to gain an insight into the assembly process. Thioflavin T, a commonly used stain for β-sheets, appears to act as a molecular rotor in these gelling systems, with the fluorescence data closely matching that of other rotors. The molecular rotor was incorporated into an assay system with glucose oxidase to enable glucose-concentration specific gelation and hence generating a fluorescent output. Applying this system to urine from patients with various levels of glycosuria (a symptom of diabetes), it was found to provide excellent correlation with different clinical assessments of diabetes. This demonstrates a new concept in gelation-linked biosensing for a real clinical problem.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Gelation, Fluorescent probes
Journal or Publication Title: Soft matter
Publisher: Royal Society of Chemistry
ISSN: 1744-683X
Official Date: 14 May 2015
Dates:
DateEvent
14 May 2015Published
24 February 2015Available
17 March 2015Accepted
24 February 2015Submitted
Volume: 11
Number: 18
Number of Pages: 8
Page Range: pp. 3706-3713
DOI: 10.1039/c5sm00456j
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 30 December 2015
Date of first compliant Open Access: 30 December 2015
Funder: Engineering and Physical Sciences Research Council (EPSRC)
Grant number: EP/G012741/1 (EPSRC), EP/L021978/1 (EPSRC)

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