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Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

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Mitchell, Daniel E., Cameron, Neil R. and Gibson, Matthew I. (2015) Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation. Chemical Communications, 51 (65). pp. 12977-12980. doi:10.1039/c5cc04647e

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Official URL: http://dx.doi.org/10.1039/C5CC04647E

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Abstract

Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Faculty of Science, Engineering and Medicine > Engineering > Engineering
Faculty of Science, Engineering and Medicine > Research Centres > Molecular Organisation and Assembly in Cells (MOAC)
Library of Congress Subject Headings (LCSH): Cells -- Cryopreservation, Cryopreservation of organs, tissues, etc., Antifreeze proteins, Ice crystals -- Growth -- Prevention
Journal or Publication Title: Chemical Communications
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Official Date: 21 August 2015
Dates:
DateEvent
21 August 2015Published
8 July 2015Available
7 July 2015Accepted
5 June 2015Submitted
Volume: 51
Number: 65
Number of Pages: 4
Page Range: pp. 12977-12980
DOI: 10.1039/c5cc04647e
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Royal Society (Great Britain), Engineering and Physical Sciences Research Council (EPSRC)
Grant number: EP/F500378/1 (EPSRC)

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