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Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation
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Mitchell, Daniel E., Cameron, Neil R. and Gibson, Matthew I. (2015) Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation. Chemical Communications, 51 (65). pp. 12977-12980. doi:10.1039/c5cc04647e ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/C5CC04647E
Abstract
Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | Q Science > QP Physiology | ||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Research Centres > Molecular Organisation and Assembly in Cells (MOAC) |
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| Library of Congress Subject Headings (LCSH): | Cells -- Cryopreservation, Cryopreservation of organs, tissues, etc., Antifreeze proteins, Ice crystals -- Growth -- Prevention | ||||||||||
| Journal or Publication Title: | Chemical Communications | ||||||||||
| Publisher: | Royal Society of Chemistry | ||||||||||
| ISSN: | 1359-7345 | ||||||||||
| Official Date: | 21 August 2015 | ||||||||||
| Dates: |
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| Volume: | 51 | ||||||||||
| Number: | 65 | ||||||||||
| Number of Pages: | 4 | ||||||||||
| Page Range: | pp. 12977-12980 | ||||||||||
| DOI: | 10.1039/c5cc04647e | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
| Date of first compliant deposit: | 30 December 2015 | ||||||||||
| Date of first compliant Open Access: | 30 December 2015 | ||||||||||
| Funder: | Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Royal Society (Great Britain), Engineering and Physical Sciences Research Council (EPSRC) | ||||||||||
| Grant number: | EP/F500378/1 (EPSRC) |
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