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Addressing the Achilles' heel in the HIV care continuum for the success of a test-and-treat strategy to achieve an AIDS-free generation
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Nachega, Jean B., Uthman, Olalekan A., Rio, Carlos del, Mugavero, Michael J., Rees, Helen and Mills, Edward (2014) Addressing the Achilles' heel in the HIV care continuum for the success of a test-and-treat strategy to achieve an AIDS-free generation. Clinical Infectious Diseases, 59 (Supplement 1). S21-S27. doi:10.1093/cid/ciu299 ISSN 1058-4838.
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Official URL: http://dx.doi.org/10.1093/cid/ciu299
Abstract
Mathematical models and recent data from ecological, observational, and experimental studies show that antiretroviral therapy (ART) is effective for both treatment and prevention of HIV, validating the treatment as prevention (TasP) approach. Data from a variety of settings, including resource-rich and -limited sites, show that patient attrition occurs at each stage of the human immunodeficiency virus (HIV) treatment cascade, starting with the percent unaware of their HIV infection in a population and linkage to care after diagnosis, assessment of ART readiness, receipt of ART, and finally long-term virologic suppression. Therefore, in order to implement TasP, we must first define practical and effective linkage to care, acceptability of treatment, and adherence and retention monitoring strategies, as well as the cost-effectiveness of such strategies. Ending this pandemic will require the combination of political will, resources, and novel effective interventions that are not only feasible and cost effective but also likely to be used in combination across successive steps on the HIV treatment cascade.
Item Type: | Journal Article | ||||||||||||||||||||||||
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Subjects: | R Medicine > RA Public aspects of medicine | ||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | AIDS (Disease)., HIV infections., HIV infections -- Prevention., AIDS (Disease) -- Treatment., Highly active antiretroviral therapy. | ||||||||||||||||||||||||
Journal or Publication Title: | Clinical Infectious Diseases | ||||||||||||||||||||||||
Publisher: | University of Chicago Press | ||||||||||||||||||||||||
ISSN: | 1058-4838 | ||||||||||||||||||||||||
Official Date: | 1 July 2014 | ||||||||||||||||||||||||
Dates: |
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Volume: | 59 | ||||||||||||||||||||||||
Number: | Supplement 1 | ||||||||||||||||||||||||
Page Range: | S21-S27 | ||||||||||||||||||||||||
DOI: | 10.1093/cid/ciu299 | ||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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