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Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults: the ZENITH study

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Maylor, Elizabeth A., Simpson, Ellen E. A., Secker, David L., Meunier, Nathalie, Andriollo-Sanchez, Maud, Polito, Angela, Stewart-Knox, Barbara, McConville, Chris, O'Connor, Jacqueline M. and Coudray , Charles. (2006) Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults: the ZENITH study. British Journal of Nutrition, Vol.96 (No.4). pp. 752-760. ISSN 0007-1145

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Official URL: http://dx.doi.org/10.1079/BJN20061911

Abstract

A randomised double-blind placebo-controlled design was employed to investigate the effects of Zn supplementation on cognitive function in 387 healthy adults aged 55–87 years. Several measures of visual memory, working memory, attention and reaction time were obtained using the Cambridge Automated Neuropsychological Test Battery at baseline and then after 3 and 6 months of 0 (placebo), 15 or 30 mg Zn/d. Younger adults (<70 years) performed significantly better on all tests than older adults (>70 years), and performance improved with practice on some measures. For two out of eight dependent variables, there were significant interactions indicating a beneficial effect (at 3 months only) of both 15 and 30 mg/d on one measure of spatial working memory and a detrimental effect of 15 mg/d on one measure of attention. Further work is required to establish whether these findings generalise to older adults in poorer mental and physical health and with less adequate Zn intake and status than the present sample.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Faculty of Science > Psychology
Library of Congress Subject Headings (LCSH):	Zinc -- Physiological effect, Neuropsychological tests -- Great Britain, Cognition -- Age factors, Cognition -- Testing, Nutrition -- Research -- Great Britain, Dietary supplements
Journal or Publication Title:	British Journal of Nutrition
Publisher:	Cambridge University Press
ISSN:	0007-1145
Date:	October 2006
Volume:	Vol.96
Number:	No.4
Page Range:	pp. 752-760
Identification Number:	10.1079/BJN20061911
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	European Commission (EC)
Grant number:	QLK1-CT-2001-00 168 (EC)
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URI:	http://wrap.warwick.ac.uk/id/eprint/713