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Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats
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Gravius, Andreas, Dekundy, Andrzej, Nagel, Jens, Morè, Lorenzo, Pietraszek, Małgorzata and Danysz, Wojciech (2008) Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats. Journal of Neural Transmission, 115 (12). pp. 1609-1619. doi:10.1007/s00702-008-0098-4 ISSN 1435-1463.
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Official URL: http://dx.doi.org/10.1007/s00702-008-0098-4
Abstract
In the present study, we evaluated the effects of subchronic blockade of mGluR5 by 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) on learning, anxiety and levodopa-induced dyskinesia in rats. In addition, we excluded the possibility that subchronic treatment produced pharmacokinetic changes using brain microdialysis. MTEP (5 mg/kg) impaired spatial learning in a radial maze task and contextual fear conditioning (CFC) when administered acutely, and the same effect was observed following a 4-day pre-treatment regime. Similarly, MTEP (5 mg/kg) exerted anxiolytic-like effects in CFC when given before the test whether administered after acute or sub-chronic treatment. Similarly, in levodopa-induced dyskinesia, sub-chronic (7 subsequent days) treatment with MTEP (5 mg/kg) resulted in a significant reduction in abnormal involuntary movements (AIMs), comparable to single acute administration. The data indicate that tolerance does not develop to the anxiolytic and antidyskinetic effects of mGluR5 antagonist MTEP at least at the used treatment mode and tested doses. However, at least at the doses tested, also no tolerance to the memory impairing effect of MTEP was observed. Depending on the indication and model, the amnesic effects of MTEP should be taken into account as a potential limitation, also after repetitive treatment.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| Library of Congress Subject Headings (LCSH): | Neurosciences, Movement disorders -- Physiological aspects, Anxiety -- Physiological aspects, Learning -- Physiological aspects | ||||
| Journal or Publication Title: | Journal of Neural Transmission | ||||
| Publisher: | Springer Wien | ||||
| ISSN: | 1435-1463 | ||||
| Official Date: | 2008 | ||||
| Dates: |
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| Volume: | 115 | ||||
| Number: | 12 | ||||
| Page Range: | pp. 1609-1619 | ||||
| DOI: | 10.1007/s00702-008-0098-4 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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