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Aggregation and fibrillization of prions in lipid membranes
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UNSPECIFIED (2005) Aggregation and fibrillization of prions in lipid membranes. In: Annual Symposium of the Biochemical-Society on Lipids, Rafts and Traffic held at the BioScience 2004 Conference, Glasgow, SCOTLAND, JUL, 2004. Published in: LIPIDS, RAFTS AND TRAFFIC, 72 pp. 211-222. ISBN 1-85578-162-X. ISSN 0067-8694.
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Abstract
A key molecular event in prion diseases is the conversion of PrP (prion protein) from its normal cellular form (PrPc) into the disease-specific form (PrPSc). The transition from PrPc to PrPSc involves a major conformational change, resulting in amorphous aggregates and/or fibrillar amyloid deposits. Here, we review several lines of evidence implicating membranes in the conversion of PrP, and summarize recent results from our own work on the role of lipid membranes in conformational transitions of prion proteins. By establishing new correlations between in vivo biological findings with in vitro biophysical results, we propose a role for lipid rafts in prion conversion, which takes into account the structural heterogeneity of PrP in different lipid environments.
Item Type: | Conference Item (UNSPECIFIED) | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Series Name: | BIOCHEMICAL SOCIETY SYMPOSIUM | ||||
Journal or Publication Title: | LIPIDS, RAFTS AND TRAFFIC | ||||
Publisher: | PORTLAND PRESS LTD | ||||
ISBN: | 1-85578-162-X | ||||
ISSN: | 0067-8694 | ||||
Editor: | McIlhinney, RAJ and Hooper, NM | ||||
Official Date: | 2005 | ||||
Dates: |
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Volume: | 72 | ||||
Number of Pages: | 12 | ||||
Page Range: | pp. 211-222 | ||||
Publication Status: | Published | ||||
Title of Event: | Annual Symposium of the Biochemical-Society on Lipids, Rafts and Traffic held at the BioScience 2004 Conference | ||||
Location of Event: | Glasgow, SCOTLAND | ||||
Date(s) of Event: | JUL, 2004 |
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