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Cell mechanics in biomedical cavitation
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Wang, Qianxi, Manmi, Kawa and Liu, Kuo-Kang (2015) Cell mechanics in biomedical cavitation. Interface focus, 5 (5). 20150018. doi:10.1098/rsfs.2015.0018 ISSN 2042-8898.
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Official URL: http://dx.doi.org/10.1098/rsfs.2015.0018
Abstract
Studies on the deformation behaviours of cellular entities, such as coated microbubbles and liposomes subject to a cavitation flow, become increasingly important for the advancement of ultrasonic imaging and drug delivery. Numerical simulations for bubble dynamics of ultrasound contrast agents based on the boundary integral method are presented in this work. The effects of the encapsulating shell are estimated by adapting Hoff's model used for thin-shell contrast agents. The viscosity effects are estimated by including the normal viscous stress in the boundary condition. In parallel, mechanical models of cell membranes and liposomes as well as state-of-the-art techniques for quantitative measurement of viscoelasticity for a single cell or coated microbubbles are reviewed. The future developments regarding modelling and measurement of the material properties of the cellular entities for cutting-edge biomedical applications are also discussed.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QR Microbiology | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||
Library of Congress Subject Headings (LCSH): | Cavitation, Microbubbles, Biomechanics, Cells -- Mechanical properties | ||||||
Journal or Publication Title: | Interface focus | ||||||
Publisher: | Royal Society Publishing | ||||||
ISSN: | 2042-8898 | ||||||
Official Date: | 21 August 2015 | ||||||
Dates: |
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Volume: | 5 | ||||||
Number: | 5 | ||||||
Article Number: | 20150018 | ||||||
DOI: | 10.1098/rsfs.2015.0018 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 31 December 2015 | ||||||
Date of first compliant Open Access: | 21 August 2016 |
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