Similarities of K-ATP(+) channel expression and Ca2+ changes in pancreatic beta cells and hypothalamic neurons
UNSPECIFIED. (2005) Similarities of K-ATP(+) channel expression and Ca2+ changes in pancreatic beta cells and hypothalamic neurons. PANCREAS, 30 (3). pp. 227-232. ISSN 0885-3177Full text not available from this repository.
The mechanisms through which pancreatic beta cells recognize and respond to changes in circulating glucose are well understood. Evidence is accumulating that a subpopulation of neurons in the ventromedial hypothalamus (VMH) use similar cellular mechanisms to sense changes in extracellular glucose. In the present study, we used PCR and single-cell calcium imaging techniques to investigate whether glucose-sensing cells in the pancreas and hypothalamus employ a similar set of stimulus-response elements. Dispersed cells from mouse pancreata and hypothalamus were used in conjunction with the insulin-secreting cell line MIN6. We present functional data suggesting that both pancreatic and a subpopulation of hypothalamic cells exhibit glucose- and tolbutamide-evoked changes in cytosolic calcium and consider some clinical implications of different glucose sensors using the same mechanisms.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine|
|Journal or Publication Title:||PANCREAS|
|Publisher:||LIPPINCOTT WILLIAMS & WILKINS|
|Official Date:||April 2005|
|Number of Pages:||6|
|Page Range:||pp. 227-232|
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