UNSPECIFIED (2005) Similarities of K-ATP(+) channel expression and Ca2+ changes in pancreatic beta cells and hypothalamic neurons. PANCREAS, 30 (3). pp. 227-232. ISSN 0885-3177

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Abstract

The mechanisms through which pancreatic beta cells recognize and respond to changes in circulating glucose are well understood. Evidence is accumulating that a subpopulation of neurons in the ventromedial hypothalamus (VMH) use similar cellular mechanisms to sense changes in extracellular glucose. In the present study, we used PCR and single-cell calcium imaging techniques to investigate whether glucose-sensing cells in the pancreas and hypothalamus employ a similar set of stimulus-response elements. Dispersed cells from mouse pancreata and hypothalamus were used in conjunction with the insulin-secreting cell line MIN6. We present functional data suggesting that both pancreatic and a subpopulation of hypothalamic cells exhibit glucose- and tolbutamide-evoked changes in cytosolic calcium and consider some clinical implications of different glucose sensors using the same mechanisms.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Journal or Publication Title:	PANCREAS
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
ISSN:	0885-3177
Date:	April 2005
Volume:	30
Number:	3
Number of Pages:	6
Page Range:	pp. 227-232
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/7213

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