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Ribosome-inactivating proteins: Entry into mammalian cells and intracellular routing

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UNSPECIFIED (2004) Ribosome-inactivating proteins: Entry into mammalian cells and intracellular routing. [Journal Item]

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Abstract

To catalytically-modify ribosomes in vivo, ribosome-inactivating proteins produced by plants must enter susceptible mammalian cells in order to reach their substrates in the cytosol. This review primarily focuses on the biosynthesis, mechanism of cell entry and intracellular trafficking of ricin, the most thoroughly studied ribosome-inactivating protein in this respect.

Item Type: Journal Item
Subjects: Q Science > QD Chemistry
Journal or Publication Title: MINI-REVIEWS IN MEDICINAL CHEMISTRY
Publisher: BENTHAM SCIENCE PUBL LTD
ISSN: 1389-5575
Date: June 2004
Volume: 4
Number: 5
Number of Pages: 8
Page Range: pp. 505-512
Publication Status: Published
URI: http://wrap.warwick.ac.uk/id/eprint/7218

Data sourced from Thomson Reuters' Web of Knowledge

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