Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, James, Jones, Kevin, Coleman, Tanya and Wood, Gemma (2009) Compartmental modelling of the pharmacokinetics of a breast cancer resistance protein. In: 7th IFAC Symposium on Modelling and Control in Biomedical Systems, Hvide Hus, Denmark. Published in: Modeling and Control in Biomedical Systems, 7 (1). pp. 115-120. doi:10.3182/20090812-3-DK-2006.00020 ISSN 1474-6670.

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Abstract

A mathematical model for the pharmacokinetics of Hoechst 33342 following administration into a culture medium containing a population of transfected cells (HEK293 hBCRP) with a potent inhibitor, Fumitremorgin C (FTC), present is described. This non-linear compartmental model has seven macroscopic sub-units, with fourteen rate parameters. A kinetic modelling software package, namely FACSIMILE (MPCA Software, UK), was used to obtain numerical solutions for the system equations and for parameter fitting. Model fits gave good agreement with in-vitro data provided by AstraZeneca.

Item Type:	Conference Item (Paper)
Divisions:	Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group)
Journal or Publication Title:	Modeling and Control in Biomedical Systems
ISSN:	1474-6670
Book Title:	7th IFAC Symposium on Modelling and Control in Biomedical Systems
Official Date:	2009
Dates:	Date Event 2009 Published
Volume:	7
Number:	1
Page Range:	pp. 115-120
DOI:	10.3182/20090812-3-DK-2006.00020
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Conference Paper Type:	Paper
Title of Event:	7th IFAC Symposium on Modelling and Control in Biomedical Systems
Type of Event:	Other
Location of Event:	Hvide Hus, Denmark

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