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Easy to synthesize, robust organo-osmium asymmetric transfer hydrogenation catalysts
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Coverdale, James P. C., Sanchez-Cano, Carlos, Clarkson, Guy J., Soni, Rina, Wills, Martin and Sadler, P. J. (2015) Easy to synthesize, robust organo-osmium asymmetric transfer hydrogenation catalysts. Chemistry - A European Journal, 21 (22). pp. 8043-8046. doi:10.1002/chem.201500534 ISSN 0947-6539.
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Official URL: http://dx.doi.org/10.1002/chem.201500534
Abstract
Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori-type RuII catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X-ray crystal structures of the 16-electron OsII catalysts are almost identical to those of RuII. Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The OsII catalysts are readily synthesised (within 1 h) and exhibit excellent enantioselectivity in ATH reactions of ketones.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Organometallic compounds, Osmium, Hydrogen ions, Asymmetric synthesis, Catalysis | ||||||||
Journal or Publication Title: | Chemistry - A European Journal | ||||||||
Publisher: | Wiley Blackwell | ||||||||
ISSN: | 0947-6539 | ||||||||
Official Date: | May 2015 | ||||||||
Dates: |
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Volume: | 21 | ||||||||
Number: | 22 | ||||||||
Page Range: | pp. 8043-8046 | ||||||||
DOI: | 10.1002/chem.201500534 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 17 April 2018 | ||||||||
Date of first compliant Open Access: | 17 April 2018 | ||||||||
Funder: | European Research Council (ERC), Engineering and Physical Sciences Research Council (EPSRC), Warwick Collaborative Postgraduate Research Scholarship (WCPRS), Leverhulme Trust (LT) | ||||||||
Grant number: | 247450, EP/F034210/1, RGP 374 |
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