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Amnioinfusion for the prevention of the meconium aspiration syndrome
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Fraser, William D., Hofmeyr, Justus, Lede, Roberto, Faron, Gilles, Alexander, Sophie, Goffinet, François, Ohlsson, Arne, Goulet, Céline, Turcot-Lemay, Lucile, Prendiville, Walter, Marcoux, Sylvie, Laperrière, Louise, Roy, Chantal, Petrou, Stavros, Xu, Hai-Rong and Wei, Bin (2005) Amnioinfusion for the prevention of the meconium aspiration syndrome. New England Journal Of Medicine , 353 (9). pp. 909-917. doi:10.1056/NEJMoa050223 ISSN 0028-4793.
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Official URL: http://dx.doi.org/10.1056/NEJMoa050223
Abstract
BACKGROUND
It is uncertain whether amnioinfusion (infusion of saline into the amniotic cavity) in women who have thick meconium staining of the amniotic fluid reduces the risk of perinatal death, moderate or severe meconium aspiration syndrome, or both.
METHODS
We performed a multicenter trial in which 1998 pregnant women in labor at 36 or more weeks of gestation who had thick meconium staining of the amniotic fluid were stratified according to the presence or absence of variable decelerations in fetal heart rate and then randomly assigned to amnioinfusion or to standard care. The composite primary outcome measure was perinatal death, moderate or severe meconium aspiration syndrome, or both.
RESULTS
Perinatal death, moderate or severe meconium aspiration syndrome, or both occurred in 44 infants (4.5 percent) of women in the amnioinfusion group and 35 infants (3.5 percent) of women in the control group (relative risk, 1.26; 95 percent confidence interval, 0.82 to 1.95). Five perinatal deaths occurred in the amnioinfusion group and five in the control group. The rate of cesarean delivery was 31.8 percent in the amnioinfusion group and 29.0 percent in the control group (relative risk, 1.10; 95 percent confidence interval, 0.96 to 1.25).
CONCLUSIONS
For women in labor who have thick meconium staining of the amniotic fluid, amnioinfusion did not reduce the risk of moderate or severe meconium aspiration syndrome, perinatal death, or other major maternal or neonatal disorders.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | New England Journal Of Medicine | ||||
Publisher: | Massachusetts Medical Society | ||||
ISSN: | 0028-4793 | ||||
Official Date: | 2005 | ||||
Dates: |
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Volume: | 353 | ||||
Number: | 9 | ||||
Page Range: | pp. 909-917 | ||||
DOI: | 10.1056/NEJMoa050223 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
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