The Library
Comparative genomics of mycoplasma : analysis of conserved essential genes and diversity of the pan-genome
Tools
Liu, Wei, Fang, Liurong, Li, Mao, Li, Sha, Guo, Shaohua, Luo, Rui, Feng, Zhixin, Li, Bin, Zhou, Zhemin, Shao, Guoqing, Chen, Huanchun and Xiao, Shaobo (2012) Comparative genomics of mycoplasma : analysis of conserved essential genes and diversity of the pan-genome. PLoS One, 7 (4). e35698. doi:10.1371/journal.pone.0035698 ISSN 1932-6203.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1371/journal.pone.0035698
Abstract
Mycoplasma, the smallest self-replicating organism with a minimal metabolism and little genomic redundancy, is expected to be a close approximation to the minimal set of genes needed to sustain bacterial life. This study employs comparative evolutionary analysis of twenty Mycoplasma genomes to gain an improved understanding of essential genes. By analyzing the core genome of mycoplasmas, we finally revealed the conserved essential genes set for mycoplasma survival. Further analysis showed that the core genome set has many characteristics in common with experimentally identified essential genes. Several key genes, which are related to DNA replication and repair and can be disrupted in transposon mutagenesis studies, may be critical for bacteria survival especially over long period natural selection. Phylogenomic reconstructions based on 3,355 homologous groups allowed robust estimation of phylogenetic relatedness among mycoplasma strains. To obtain deeper insight into the relative roles of molecular evolution in pathogen adaptation to their hosts, we also analyzed the positive selection pressures on particular sites and lineages. There appears to be an approximate correlation between the divergence of species and the level of positive selection detected in corresponding lineages.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
Journal or Publication Title: | PLoS One | ||||
Publisher: | Public Library of Science | ||||
ISSN: | 1932-6203 | ||||
Official Date: | 2012 | ||||
Dates: |
|
||||
Volume: | 7 | ||||
Number: | 4 | ||||
Article Number: | e35698 | ||||
DOI: | 10.1371/journal.pone.0035698 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |