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Multiple-bolus dynamic contrast-enhanced MRI in the pancreas during a glucose challenge
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Naish, J. H., Hutchinson, Charles E., Caunce, A., Roberts, C., Waterton, J. C., Hockings, P. D., Taylor, C. J. and Parker, G. J. M. (2010) Multiple-bolus dynamic contrast-enhanced MRI in the pancreas during a glucose challenge. Journal of Magnetic Resonance Imaging, 32 (3). pp. 622-628. doi:10.1002/jmri.22281
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Official URL: http://dx.doi.org/10.1002/jmri.22281
Abstract
Purpose:
To assess the feasibility of multiple-bolus dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in the pancreas; to optimize the analysis; and to investigate application of the method to a glucose challenge in type 2 diabetes.
Materials and Methods:
A 4-bolus DCE-MRI protocol was performed on five patients with type 2 diabetes and 11 healthy volunteers during free-breathing. Motion during the dynamic time series was corrected for using a model-driven nonlinear registration. A glucose challenge was administered intravenously between the first and second DCE-MRI acquisition in all patients and in seven of the healthy controls.
Results:
Image registration improved the reproducibility of the DCE-MRI model parameters across the repeated bolus-acquisitions in the healthy controls with no glucose challenge (eg, coefficient of variation for Ktrans improved from 38% to 28%). Native tissue T1 was significantly lower in patients (374 ± 68 msec) compared with volunteers (519 ± 41 msec) but there was no significant difference in any of the baseline DCE-MRI parameters. No effect of glucose challenge was observed in either the patients or healthy volunteers.
Conclusion:
Multiple bolus DCE-MRI is feasible in the pancreas and is improved by nonlinear image registration but is not sensitive to the effects of an intravenous glucose challenge. J. Magn. Reson. Imaging 2010;32:622–628.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Journal of Magnetic Resonance Imaging | ||||
| Publisher: | John Wiley & Sons | ||||
| ISSN: | 1053-1807 | ||||
| Official Date: | September 2010 | ||||
| Dates: |
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| Volume: | 32 | ||||
| Number: | 3 | ||||
| Page Range: | pp. 622-628 | ||||
| DOI: | 10.1002/jmri.22281 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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