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Multiple-bolus dynamic contrast-enhanced MRI in the pancreas during a glucose challenge

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Naish, J. H., Hutchinson, Charles E., Caunce, A., Roberts, C., Waterton, J. C., Hockings, P. D., Taylor, C. J. and Parker, G. J. M. (2010) Multiple-bolus dynamic contrast-enhanced MRI in the pancreas during a glucose challenge. Journal of Magnetic Resonance Imaging, 32 (3). pp. 622-628. doi:10.1002/jmri.22281

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Official URL: http://dx.doi.org/10.1002/jmri.22281

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Abstract

Purpose:
To assess the feasibility of multiple-bolus dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in the pancreas; to optimize the analysis; and to investigate application of the method to a glucose challenge in type 2 diabetes.

Materials and Methods:
A 4-bolus DCE-MRI protocol was performed on five patients with type 2 diabetes and 11 healthy volunteers during free-breathing. Motion during the dynamic time series was corrected for using a model-driven nonlinear registration. A glucose challenge was administered intravenously between the first and second DCE-MRI acquisition in all patients and in seven of the healthy controls.

Results:
Image registration improved the reproducibility of the DCE-MRI model parameters across the repeated bolus-acquisitions in the healthy controls with no glucose challenge (eg, coefficient of variation for Ktrans improved from 38% to 28%). Native tissue T1 was significantly lower in patients (374 ± 68 msec) compared with volunteers (519 ± 41 msec) but there was no significant difference in any of the baseline DCE-MRI parameters. No effect of glucose challenge was observed in either the patients or healthy volunteers.

Conclusion:
Multiple bolus DCE-MRI is feasible in the pancreas and is improved by nonlinear image registration but is not sensitive to the effects of an intravenous glucose challenge. J. Magn. Reson. Imaging 2010;32:622–628.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET)
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Journal of Magnetic Resonance Imaging
Publisher: John Wiley & Sons
ISSN: 1053-1807
Official Date: September 2010
Dates:
DateEvent
September 2010Published
Volume: 32
Number: 3
Page Range: pp. 622-628
DOI: 10.1002/jmri.22281
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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