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Targeted therapies of the LKB1/AMPK pathway for the treatment of insulin resistance
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Yamada, Eijiro, Lee, Ting-Wen A., Pessin, Jeffrey E. and Bastie, Claire C. (2010) Targeted therapies of the LKB1/AMPK pathway for the treatment of insulin resistance. Future Medicinal Chemistry, 2 (12). pp. 1785-1796. doi:10.4155/fmc.10.264 ISSN 1756-8919.
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Official URL: http://dx.doi.org/10.4155/fmc.10.264
Abstract
Type 2 diabetes is characterized by elevated serum glucose levels and altered lipid metabolism, due to peripheral insulin resistance and defects of insulin secretion by the pancreatic β-cells. While some cases of obesity and Type 2 diabetes result from genetic dysfunction, the increased worldwide incidence of these two disorders strongly suggest that the contribution of environmental factors such as sedentary life-styles and high-calorie intake may disrupt energy balance. AMP-activated protein kinase (AMPK) and its upstream kinase LKB1 are conserved serine/threonine kinases regulating anabolic and catabolic metabolic processes, therefore representing attractive therapeutic targets for the treatment of obesity and Type 2 diabetes. In this review, we will discuss the advantages of targeting the LKB1/AMPK pathway for the treatment of metabolic diseases.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Future Medicinal Chemistry | ||||
Publisher: | Future Science Ltd. | ||||
ISSN: | 1756-8919 | ||||
Official Date: | 2010 | ||||
Dates: |
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Volume: | 2 | ||||
Number: | 12 | ||||
Page Range: | pp. 1785-1796 | ||||
DOI: | 10.4155/fmc.10.264 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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