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Disability in people clinically at high risk of psychosis

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Velthorst, E., Nieman, D. H., Linszen, D., Becker, H., de Haan, L., Dingemans, P. M., Birchwood, M. J., Patterson, Paul, Salokangas, R. K. R., Heinimaa, M., Heinz, A., Juckel, G., von Reventlow, H. G., French, P., Stevens, H., Schultze-Lutter, F., Klosterkotter, J. and Ruhrmann, S. (2010) Disability in people clinically at high risk of psychosis. The British Journal of Psychiatry, 197 (4). pp. 278-284. doi:10.1192/bjp.bp.109.075036 ISSN 0007-1250.

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Official URL: http://dx.doi.org/10.1192/bjp.bp.109.075036

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Abstract

Background: Decline in social functioning occurs in individuals who later develop psychosis.

Aims: To investigate whether baseline differences in disability are present in those who do and those who do not make a transition to psychosis in a group clinically at high risk and whether disability is a risk factor for transition.

Method: Prospective multicentre, naturalistic field study with an 18-month follow-up period on 245 help-seeking individuals clinically at high risk. Disability was assessed with the Disability Assessment Schedule of the World Health Organization (WHODAS–II).

Results: At baseline, the transition group displayed significantly greater difficulties in making new friends (z = –3.40, P = 0.001), maintaining a friendship (z =–3.00, P = 0.003), dealing with people they do not know (z =–2.28, P = 0.023) and joining community activities (z =–2.0, P = 0.05) compared with the non-transition group. In Cox regression, difficulties in getting along with people significantly contributed to the prediction of transition to psychosis in our sample (β = 0.569, s.e. = 0.184, Wald = 9.548, P = 0.002, hazard ratio (HR) = 1.767, 95% CI 1.238–2.550).

Conclusions: Certain domains of social disability might contribute to the prediction of psychosis in a sample clinically at high risk.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: The British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
ISSN: 0007-1250
Official Date: 2010
Dates:
DateEvent
2010Published
Volume: 197
Number: 4
Page Range: pp. 278-284
DOI: 10.1192/bjp.bp.109.075036
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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