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Disability in people clinically at high risk of psychosis
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Velthorst, E., Nieman, D. H., Linszen, D., Becker, H., de Haan, L., Dingemans, P. M., Birchwood, M. J., Patterson, Paul, Salokangas, R. K. R., Heinimaa, M., Heinz, A., Juckel, G., von Reventlow, H. G., French, P., Stevens, H., Schultze-Lutter, F., Klosterkotter, J. and Ruhrmann, S. (2010) Disability in people clinically at high risk of psychosis. The British Journal of Psychiatry, 197 (4). pp. 278-284. doi:10.1192/bjp.bp.109.075036 ISSN 0007-1250.
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Official URL: http://dx.doi.org/10.1192/bjp.bp.109.075036
Abstract
Background: Decline in social functioning occurs in individuals who later develop psychosis.
Aims: To investigate whether baseline differences in disability are present in those who do and those who do not make a transition to psychosis in a group clinically at high risk and whether disability is a risk factor for transition.
Method: Prospective multicentre, naturalistic field study with an 18-month follow-up period on 245 help-seeking individuals clinically at high risk. Disability was assessed with the Disability Assessment Schedule of the World Health Organization (WHODAS–II).
Results: At baseline, the transition group displayed significantly greater difficulties in making new friends (z = –3.40, P = 0.001), maintaining a friendship (z =–3.00, P = 0.003), dealing with people they do not know (z =–2.28, P = 0.023) and joining community activities (z =–2.0, P = 0.05) compared with the non-transition group. In Cox regression, difficulties in getting along with people significantly contributed to the prediction of transition to psychosis in our sample (β = 0.569, s.e. = 0.184, Wald = 9.548, P = 0.002, hazard ratio (HR) = 1.767, 95% CI 1.238–2.550).
Conclusions: Certain domains of social disability might contribute to the prediction of psychosis in a sample clinically at high risk.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | The British Journal of Psychiatry | ||||
| Publisher: | Royal College of Psychiatrists | ||||
| ISSN: | 0007-1250 | ||||
| Official Date: | 2010 | ||||
| Dates: |
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| Volume: | 197 | ||||
| Number: | 4 | ||||
| Page Range: | pp. 278-284 | ||||
| DOI: | 10.1192/bjp.bp.109.075036 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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