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Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis

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Hood, F. E. and Royle, Stephen J. (2009) Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis. Journal of Cell Science, 122 (13). pp. 2185-2190. doi:10.1242/jcs.046177 ISSN 0021-9533.

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Official URL: http://dx.doi.org/10.1242/jcs.046177

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Abstract

Clathrin is crucial for endocytosis and plays a recently described role in mitosis. Two clathrin heavy chains (CHCs) are found in humans: the ubiquitous CHC17, and CHC22, a CHC that is enriched in skeletal muscle. Functional differences have been proposed for these clathrins despite high sequence similarity. Here, we compared each paralogue in functional assays of endocytosis and mitosis. We find that CHC17 and CHC22 are functionally equivalent. We also describe how previous work on CHC22 has involved a splice variant that is not usually expressed in cells.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Journal of Cell Science
Publisher: The Company of Biologists Ltd.
ISSN: 0021-9533
Official Date: 2009
Dates:
DateEvent
2009Published
Volume: 122
Number: 13
Page Range: pp. 2185-2190
DOI: 10.1242/jcs.046177
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)

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