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Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis
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Hood, F. E. and Royle, Stephen J. (2009) Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis. Journal of Cell Science, 122 (13). pp. 2185-2190. doi:10.1242/jcs.046177
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Official URL: http://dx.doi.org/10.1242/jcs.046177
Abstract
Clathrin is crucial for endocytosis and plays a recently described role in mitosis. Two clathrin heavy chains (CHCs) are found in humans: the ubiquitous CHC17, and CHC22, a CHC that is enriched in skeletal muscle. Functional differences have been proposed for these clathrins despite high sequence similarity. Here, we compared each paralogue in functional assays of endocytosis and mitosis. We find that CHC17 and CHC22 are functionally equivalent. We also describe how previous work on CHC22 has involved a splice variant that is not usually expressed in cells.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Journal of Cell Science | ||||
| Publisher: | The Company of Biologists Ltd. | ||||
| ISSN: | 0021-9533 | ||||
| Official Date: | 2009 | ||||
| Dates: |
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| Volume: | 122 | ||||
| Number: | 13 | ||||
| Page Range: | pp. 2185-2190 | ||||
| DOI: | 10.1242/jcs.046177 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access |
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