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Retropharyngeal nodal metastasis related to higher rate of distant metastasis in patients with N0and N1nasopharyngeal cancer
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Tham, Ivan Weng-Keong, Hee, Siew Wan, Yap, Swee Peng, Tuan, Jeffrey Kit-Loong and Wee, Joseph (2009) Retropharyngeal nodal metastasis related to higher rate of distant metastasis in patients with N0and N1nasopharyngeal cancer. Head & Neck, 31 (4). pp. 468-474. doi:10.1002/hed.21008 ISSN 1043-3074.
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Official URL: http://dx.doi.org/10.1002/hed.21008
Abstract
Background:
Retropharyngeal lymph node (RLN) staging in nasopharyngeal carcinoma (NPC) can be controversial.
Methods:
We retrospectively reviewed all patients with T2–4, N0–1 NPC treated between 1992 and 1994 to examine if RLN metastasis resulted in an increased incidence of distant metastases.
Results:
Of the 667 patients with NPC, 395 had T2–4, N0–1 disease, 140 had N0, and 255 had N1. All had staging CT scans and were treated with radiotherapy. Median follow-up was 8.3 years. Seventy-four percent showed undifferentiated histology. In this cohort, 187 (47%) had RLN metastases. Multivariate analysis showed that RLN conferred a higher hazard for distant metastasis (p = .04). Using the Kaplan–Meier method, patients with N0 disease and RLN had a similar hazard for distant metastases as patients with N1 disease when compared with patients with N0 disease and without RLN.
Conclusion:
Patients with N0 disease and RLN appear to share a similar prognosis to patients with N1 disease. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Head & Neck | ||||
Publisher: | John Wiley & Sons Ltd. | ||||
ISSN: | 1043-3074 | ||||
Official Date: | April 2009 | ||||
Dates: |
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Volume: | 31 | ||||
Number: | 4 | ||||
Page Range: | pp. 468-474 | ||||
DOI: | 10.1002/hed.21008 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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