Griffin, Xavier L., Smith, C. M. and Costa, Matthew L. (2009) The clinical use of platelet-rich plasma in the promotion of bone healing : a systematic review. Injury, 40 (2). pp. 158-162. doi:10.1016/j.injury.2008.06.025

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Abstract

Platelet-rich plasma has been shown in several in vitro and animal studies to play a role in promoting new bone formation. A systematic literature review was conducted to identify the current relevant evidence base, searching across multiple sources including Medline, Embase and the Cochrane Library, and finding five clinically relevant articles. Only one was a randomised controlled trial, but this was underpowered for the outcome measure defined. Three studies exclusively concerned children, and included those with congenital limb deformities. Two other reports were case series. Early clinical results suggest that the use of platelet-rich plasma is safe and feasible, but that at present there is no clinical evidence of benefit in either acute or delayed fracture healing.

Item Type:	Journal Article
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Injury
Publisher:	Elsevier
ISSN:	0020-1383
Official Date:	2009
Dates:	Date Event 2009 Published
Volume:	40
Number:	2
Page Range:	pp. 158-162
DOI:	10.1016/j.injury.2008.06.025
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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