The Library
The West Midlands bladder cancer prognosis programme : rationale and design
Tools
Zeegers, Maurice P., Bryan, Richard T., Langford, Carolyn, Billingham, Lucinda, Murray, Paul, Deshmukh, Neeta S., Hussain, Syed, James, Nicholas D., Wallace, D. Michael A. and Cheng, K.K. (2010) The West Midlands bladder cancer prognosis programme : rationale and design. BJU International, 105 (6). pp. 784-788. doi:10.1111/j.1464-410X.2009.08849.x ISSN 1464-1603.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1111/j.1464-410X.2009.08849.x
Abstract
Objective:
To describe the rationale and design of the Bladder Cancer Prognosis Programme (BCPP), and to demonstrate the capability of this design.
Methods:
There is a need to understand the determinants of bladder cancer to help reduce recurrence, progression, morbidity, mortality and related costs. We previously showed that lifestyle factors are important for determining the risk of bladder cancer, but little is known about their importance in determining the risk of recurrence or progression after diagnosis. Also, histopathological factors alone provide only crude prognostication; the analysis of molecular markers represents a method for refinement but research in this area has not been useful in informing therapeutic decisions or prognostication. The BCPP is a prospective longitudinal cohort study of all patients with newly diagnosed bladder cancer within the West Midlands (UK), investigating the influence of lifestyle factors on recurrence and progression, health-related quality of life, the predictive effect of a panel of molecular markers on recurrence or progression, and the establishment of Europe’s largest comprehensive bladder cancer bio-repository. It also incorporates the first randomized clinical trial on the efficacy of selenium and vitamin E on bladder cancer. The numbers and proportions of eligible patients recruited, questionnaires completed and specimens obtained were all recorded.
Results:
Since December 2005, 771 patients have been recruited (68% of eligible patients) and of these, 331 are currently being followed up by questionnaires. We have obtained blood, urine and tumour tissues from 92%, 80% and 80% of patients, respectively.
Conclusions:
The design of the BCPP has allowed this study to be incorporated into routine clinical work throughout the West Midlands, achieving high levels of recruitment, and data and specimen collection. This might represent a model for the future investigation of urological and other malignancies.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Cancer Research Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
Journal or Publication Title: | BJU International | ||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||
ISSN: | 1464-1603 | ||||
Official Date: | 2010 | ||||
Dates: |
|
||||
Volume: | 105 | ||||
Number: | 6 | ||||
Page Range: | pp. 784-788 | ||||
DOI: | 10.1111/j.1464-410X.2009.08849.x | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |