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Sorafenib induces therapeutic response in a patient with metastatic collecting duct carcinoma of kidney
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Ansari, Jawaher, Fatima, Arfeen, Chaudhri, Shalini, Bhatt, Rupesh I., Wallace, Michael and James, Nicholas D. (2009) Sorafenib induces therapeutic response in a patient with metastatic collecting duct carcinoma of kidney. Onkologie , 32 (1-2). pp. 44-46. doi:10.1159/000183736 ISSN 0378-584X.
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Official URL: http://dx.doi.org/10.1159/000183736
Abstract
Background: Collecting duct carcinoma (CDC) is a rare and aggressive variant of renal cell carcinoma (RCC), which has poor response to cytokine therapy and chemotherapy. Introduction of tyrosine kinase inhibitors (TKIs), in particular sorafenib and sunitinib, is changing the treatment paradigm for management of RCC. However, patients with CDC have been excluded from the majority of randomised trials involving the use of TKIs. Case Report: Our patient with metastatic CDC was treated with sorafenib, and demonstrated an excellent response, both clinically and radiologically. She continues on sorafenib treatment with minimal toxicity, and has demonstrated a progressionfree survival exceeding 13 months. Conclusions: This is the first reported case of a patient with CDC responding to sorafenib treatment. Therefore, the role of sorafenib in the management of metastatic CDC needs prospective evaluation.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Cancer Research Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Onkologie | ||||
Publisher: | S. Karger AG | ||||
ISSN: | 0378-584X | ||||
Official Date: | 2009 | ||||
Dates: |
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Volume: | 32 | ||||
Number: | 1-2 | ||||
Page Range: | pp. 44-46 | ||||
DOI: | 10.1159/000183736 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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