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Radical radiotherapy with high-dose-rate brachytherapy for uterine cervix cancer long-term results
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Khor, T. H., Tuan, J. K. L., Hee, Siew Wan and Tham, I. W. K. (2007) Radical radiotherapy with high-dose-rate brachytherapy for uterine cervix cancer long-term results. Australasian Radiology, 51 (6). pp. 570-577. doi:10.1111/j.1440-1673.2007.01895.x ISSN 1754-9477.
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Abstract
The aim of this is to report the results of radical radiotherapy in carcinoma of the cervix treated by high-dose rate (HDR) intracavitary brachytherapy and external beam radiotherapy (XRT) at a single centre in Singapore. This is a retrospective analysis of 106 consecutive cases with histologically proven cervical cancer, treated by HDR brachytherapy and XRT at the Mount Elizabeth Hospital from 1990 to 1993. External beam radiotherapy to the pelvis was delivered with 6 MV photons, to 45–50.4 Gy in 1.8 Gy fractions. High-dose-rate brachytherapy comprised two to three applications of an intrauterine tandem with paired ovoids, to a median dose of 18 Gy to point ‘A’, carried out during XRT. All 106 patients completed treatment. Their ages ranged from 32 to 80 years (median 57 years). Most patients presented with stage II or III disease (44 and 37%, respectively) and with squamous cell carcinoma (91%). Median follow-up time was 59 months (range 2–169 months). The 5-year relapse-free survival rate across all stages was 71%. The corresponding overall survival rate was 69%. Local control was achieved in 86 patients (81%); six patients had residual disease (6%), and 14 patients had local recurrence (13%). Fourteen patients developed metastatic disease (13%). On univariate analysis, tumour stage, haemoglobin level, number of brachytherapy treatments and overall treatment time were found to be prognostic factors for overall survival. Late complications were mild (Radiation Therapy Oncology Group score 1–2), except for one patient with grade 4 rectal toxicity. The complication rates were 8, 14 and 45%, respectively, for the rectum, bladder and vagina (stenosis). The use of two to three fractions of HDR intracavitary brachytherapy in addition to pelvic XRT achieves good outcomes.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Australasian Radiology | ||||
Publisher: | Wiley-Blackwell Publishing Asia | ||||
ISSN: | 1754-9477 | ||||
Official Date: | 2007 | ||||
Dates: |
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Volume: | 51 | ||||
Number: | 6 | ||||
Page Range: | pp. 570-577 | ||||
DOI: | 10.1111/j.1440-1673.2007.01895.x | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Reuse Statement (publisher, data, author rights): | Cited By :1 Export Date: 5 March 2015 | ||||
Access rights to Published version: | Restricted or Subscription Access |
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