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A phase II trial of induction gemcitabine and vinorelbine followed by concurrent vinorelbine and radiotherapy in locally advanced non-small cell lung cancer
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Leong, S. S., Fong, K. W., Lim, W. T., Toh, C. K., Yap, S. P., Hee, Siew Wan and Tan, E. H. (2010) A phase II trial of induction gemcitabine and vinorelbine followed by concurrent vinorelbine and radiotherapy in locally advanced non-small cell lung cancer. Lung Cancer, 67 (3). pp. 325-329. doi:10.1016/j.lungcan.2009.04.022
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Official URL: http://dx.doi.org/10.1016/j.lungcan.2009.04.022
Abstract
This is phase II study evaluating a non-platinum-containing regimen, used in conjunction with radiotherapy, in patients with locally advanced non-small cell lung cancer (NSCLC). Patients with non-resectable stage III NSCLC were treated with two cycles of induction gemcitabine (1000 mg/m2) and vinorelbine (25 mg/m2) given on D1,8 every 21 days, followed by thoracic radiotherapy (60–66 Gy) with concurrent weekly vinorelbine (15 mg/m2). The primary objective was to assess response rate and secondary objectives to assess tolerability and to determine the progression-free survival (PFS) and overall survival (OS). Of the 42 patients enrolled on the study, 15 (36%) achieved a partial response (PR) after induction chemotherapy. After chemo-radiotherapy, five patients had complete response (CR) and 19 patients had PR, giving an overall response rate of 52%. The median PFS was 8 months and median OS was 17 months. The regimen was tolerable, with a 21% grade 3/4 neutropenia rate and 38% grade 2/3 esophagitis rate.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Lung Cancer | ||||
| Publisher: | Elsevier | ||||
| ISSN: | 5002 | ||||
| Official Date: | 2010 | ||||
| Dates: |
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| Volume: | 67 | ||||
| Number: | 3 | ||||
| Page Range: | pp. 325-329 | ||||
| DOI: | 10.1016/j.lungcan.2009.04.022 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Publisher Statement: | Cited By :3 Export Date: 5 March 2015 | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
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