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Comparative analysis of extra-nodal NK/T-cell lymphoma and peripheral T-cell lymphoma : significant differences in clinical characteristics and prognosis
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Lim, S. T., Hee, Siew Wan, Quek, R., Lim, L. C., Yap, S. P., Loong, E. L., Sng, I., Tan, L. H. C., Ang, M. K., Ngeow, J., Tham, C. K., Ngo, L., Tan, M. H. and Tao, M. (2008) Comparative analysis of extra-nodal NK/T-cell lymphoma and peripheral T-cell lymphoma : significant differences in clinical characteristics and prognosis. European Journal of Haematology, 80 (1). pp. 55-60. doi:10.1111/j.1600-0609.2007.00978.x
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Official URL: http://dx.doi.org/10.1111/j.1600-0609.2007.00978.x
Abstract
Aim: We aimed to compare the frequencies, clinical characteristics, and prognostic factors of peripheral T-cell lymphoma (PTCL) vs. extra-nodal natural killer (NK)/T-cell lymphoma and to characterize the subtypes of extra-nodal NK/T-cell lymphoma. Methods: We reviewed 97 consecutive patients with PTCL and extra-nodal NKT lymphoma from 2000 to 2006. During this period, a total of 780 patients with malignant lymphomas were treated in our center. The diagnostic criteria used were based on the WHO classification system of malignant lymphomas. Results: Extra-nodal-NK/T-cell lymphoma and PTCL comprised 5.0% (39/780) and 7.4% (58/780) of all cases. Of the PTCL cases, histology was PTCL-NOS in 25, anaplastic large cell in 11, angioimmunoblastic T cell in 18 and other subtypes in four patients. Compared with PTCL, extra-nodal NK/T-cell lymphoma was associated with a significantly inferior rates of complete remission (33% vs. 53%, P = 0.05) and 3 yr overall survival (29.5% vs. 47.5%, P = 0.003). On multivariate analysis, extra-nodal NK/T-cell histology was independently associated with decreased survival. Further analysis into this subtype showed the nasal variant (n = 25) differed significantly from extra-nasal variant (n = 14) in terms of stage at presentation (stages III/IV, 36% vs. 79%), international prognostic index scores (high intermediate or high IPI scores, 24% vs. 64%), complete remission rates (48% vs. 7%), and median survival (10 months vs. 1 month, P < 0.0001). Conclusions: Extra-nodal NK/T-cell lymphoma was associated with a poorer prognosis compared with PTCL and is likely to comprise two distinct variants with different clinical behavior and prognosis.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | European Journal of Haematology | ||||
| Publisher: | Wiley-Blackwell Publishing, Inc. | ||||
| ISSN: | 0902-4441 | ||||
| Official Date: | 2008 | ||||
| Dates: |
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| Volume: | 80 | ||||
| Number: | 1 | ||||
| Page Range: | pp. 55-60 | ||||
| DOI: | 10.1111/j.1600-0609.2007.00978.x | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Publisher Statement: | Cited By :23 Export Date: 5 March 2015 | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
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