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Primary central nervous system lymphoma in an Asian population : a 15-year experience
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Quek, R., Ty, A., Lim, S. T., See, S. J., Wong, M. C., Yap, S. P., Sng, I., Hee, Siew Wan and Tao, M. (2006) Primary central nervous system lymphoma in an Asian population : a 15-year experience. Oncology Research and Treatment, 29 (10). pp. 455-459. doi:10.1159/000095342
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Official URL: http://dx.doi.org/10.1159/000095342
Abstract
The aim of this study was to characterize primary central nervous system lymphoma (PCNSL) among Asian patients and to determine their outcomes with different therapeutic modalities. Patients and Methods: Between 1990 and 2005, 37 patients with PCNSL were analyzed within 5 different treatment groups: radiotherapy alone (arm A), combined chemoradiation (arm B), chemotherapy alone with methotrexate (MTX) ≥ 1 g/m<sup>2</sup> (arm C), miscellaneous therapy (arm D), and best supportive care (arm E). Results: The median age at presentation was 59 years, and the majority of patients were male (68). All patients had aggressive diffuse large B-cell lymphoma. The number of patients in arms A to E were 6, 16, 3, 8 and 4, respectively. The overall median survival was 7.4 months, 54.1 months, not reached, 8.9 months and 0.9 months, respectively. Use of MTX 1-2.5 g/m<sup>2</sup> per cycle and an ECOG performance status of 0-2 were each associated with improved survival on univariate analysis (p = 0.022 and p = 0.049, respectively). Compared to radiotherapy alone, use of combined chemo-radiation was associated with a trend towards improved overall median survival (7.4 vs. 54.1 months, p = 0.058). Conclusion: The clinical characteristics and treatment outcomes in our Asian patients were comparable to those reported in Western series. Use of MTX 1-2.5 g/m<sup>2</sup> per cycle and an ECOG performance status of 0-2 were associated with improved survival.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Oncology Research and Treatment | ||||
| Publisher: | S. Karger AG | ||||
| ISSN: | 2296-5270 | ||||
| Official Date: | 2006 | ||||
| Dates: |
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| Volume: | 29 | ||||
| Number: | 10 | ||||
| Page Range: | pp. 455-459 | ||||
| DOI: | 10.1159/000095342 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Related URLs: |
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