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Primary central nervous system lymphoma in an Asian population : a 15-year experience

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Quek, R., Ty, A., Lim, S. T., See, S. J., Wong, M. C., Yap, S. P., Sng, I., Hee, Siew Wan and Tao, M. (2006) Primary central nervous system lymphoma in an Asian population : a 15-year experience. Oncology Research and Treatment, 29 (10). pp. 455-459. doi:10.1159/000095342

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Official URL: http://dx.doi.org/10.1159/000095342

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Abstract

The aim of this study was to characterize primary central nervous system lymphoma (PCNSL) among Asian patients and to determine their outcomes with different therapeutic modalities. Patients and Methods: Between 1990 and 2005, 37 patients with PCNSL were analyzed within 5 different treatment groups: radiotherapy alone (arm A), combined chemoradiation (arm B), chemotherapy alone with methotrexate (MTX) &#8805; 1 g/m<sup>2</sup> (arm C), miscellaneous therapy (arm D), and best supportive care (arm E). Results: The median age at presentation was 59 years, and the majority of patients were male (68). All patients had aggressive diffuse large B-cell lymphoma. The number of patients in arms A to E were 6, 16, 3, 8 and 4, respectively. The overall median survival was 7.4 months, 54.1 months, not reached, 8.9 months and 0.9 months, respectively. Use of MTX 1-2.5 g/m<sup>2</sup> per cycle and an ECOG performance status of 0-2 were each associated with improved survival on univariate analysis (p = 0.022 and p = 0.049, respectively). Compared to radiotherapy alone, use of combined chemo-radiation was associated with a trend towards improved overall median survival (7.4 vs. 54.1 months, p = 0.058). Conclusion: The clinical characteristics and treatment outcomes in our Asian patients were comparable to those reported in Western series. Use of MTX 1-2.5 g/m<sup>2</sup> per cycle and an ECOG performance status of 0-2 were associated with improved survival.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Oncology Research and Treatment
Publisher: S. Karger AG
ISSN: 2296-5270
Official Date: 2006
Dates:
DateEvent
2006Published
Volume: 29
Number: 10
Page Range: pp. 455-459
DOI: 10.1159/000095342
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
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