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Survival of small-cell lung cancer and its determinants of outcome in Singapore
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Toh, C. K., Hee, Siew Wan, Lim, W. T., Leong, S. S., Fong, K. W., Yap, S. P., Hsu, A. A. L., Eng, P., Koong, H. N., Agasthian, T. and Tan, E. H. (2007) Survival of small-cell lung cancer and its determinants of outcome in Singapore. Annals of the Academy of Medicine Singapore , 36 (3). pp. 181-188.
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Official URL: http://www.annals.edu.sg/pdf/36VolNo3Mar2007/V36N3...
Abstract
Introduction: The survival and epidemiology of small-cell lung cancer (SCLC) in Singapore
has not been described. We aim to present the characteristics as well as determine the survival
outcome and important prognostic factors for SCLC patients. Materials and Methods: A
retrospective analysis of SCLC patients diagnosed from 1999 to 2002 was conducted at the
Outram campus, Singapore. Clinical characteristics and treatment data were obtained from case
records and survival data were checked with the registry of births and deaths on 30 May 2005.
Results: One hundred and eleven patients were analysed. There were 38 (34.2%) limited-disease
(LD) patients and 73 (65.8%) extensive-disease (ED) patients. The majority were current or
former smokers (94.7% among LD and 94.5% among ED). More patients with LD had good
performance status (92% versus 63%, P = 0.0003) and were treated with combined chemotherapy
and radiotherapy (82% versus 48%, P = 0.012). The median survival time of LD patients
treated with curative chemoradiotherapy was 14.2 months (95% CI, 10.96 to 17.44). Those given
prophylactic cranial irradiation had a median survival time of 16.9 months (95% CI, 11.83 to
21.97). For ED patients, the median survival time was 8.17 months (95%CI, 5.44 to 10.89). None
of the factors analysed were significant prognostic factors for LD patients while performance
status and type of treatment given were significant among ED patients. Conclusions: We found
that the characteristics and survival of SCLC patients in Singapore are fairly similar to that of
other countries.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Annals of the Academy of Medicine Singapore | ||||
| Publisher: | Academy of Medicine Singapore | ||||
| ISSN: | 0304-4602 | ||||
| Official Date: | 2007 | ||||
| Dates: |
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| Volume: | 36 | ||||
| Number: | 3 | ||||
| Page Range: | pp. 181-188 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Publisher Statement: | Cited By :6 Export Date: 5 March 2015 | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Related URLs: |
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