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Brachytherapy boost for T1/T2 nasopharyngeal carcinoma
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Yeo, R., Fong, K. W., Hee, Siew Wan, Chua, E. T., Tan, T. and Wee, J. (2009) Brachytherapy boost for T1/T2 nasopharyngeal carcinoma. Head and Neck, 31 (12). pp. 1610-1618. doi:10.1002/hed.21130 ISSN 1043-3074 .
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Abstract
Background.
The aim of this study was to review our experience and demonstrate the safety of intracavitary brachytherapy (ICB) in patients with nasopharyngeal carcinoma (NPC).
Methods.
Hundred seventy-eight patients with early T1-2b disease underwent radical external beam radiation therapy (EBRT) followed by ICB boost. The primary tumor received 66 Gy of EBRT over 33 fractions using 6 or 10 MV photons. ICB insertions were performed 1 week later, delivering 10 Gy in 2 fractions over 8 days. Kaplan-Meier survival analyses were used to calculate the actuarial 5-year overall survival (OS), cause-specific survival, local control, and disease-free survival (DFS).
Results.
Five-year local control rates were 91.6%. OS, DFS, and cause-specific survival were estimated to be 85.25%, 81.7%, and 87.9%, respectively. Median follow-up was 86 months. There were no documented serious complications noted with ICB.
Conclusion.
ICB boost supplementing radical EBRT is an excellent method of enhancing local control for patients with NPC with early T1-2b disease
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Head and Neck | ||||
Publisher: | John Wiley & Sons, Inc. | ||||
ISSN: | 1043-3074 | ||||
Official Date: | 2009 | ||||
Dates: |
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Volume: | 31 | ||||
Number: | 12 | ||||
Page Range: | pp. 1610-1618 | ||||
DOI: | 10.1002/hed.21130 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Reuse Statement (publisher, data, author rights): | Cited By :7 Export Date: 5 March 2015 | ||||
Access rights to Published version: | Restricted or Subscription Access |
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