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Speeding up the evaluation of new agents in cancer
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Parmar, Mahesh K. B., Barthel, F. M.- S., Sydes, Matthew R., Langley, R., Kaplan, R., Eisenhauer, E., Brady, M., James, Nicholas D., Bookman, M. A., Swart, A.-M., Qian, W. and Royston, P. (2008) Speeding up the evaluation of new agents in cancer. JNCI Journal of the National Cancer Institute, 100 (17). pp. 1204-1214. doi:10.1093/jnci/djn267 ISSN 0027-8874.
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Official URL: http://dx.doi.org/10.1093/jnci/djn267
Abstract
Despite both the increase in basic biologic knowledge and the fact that many new agents have reached various stages of development during the last 10 years, the number of new treatments that have been approved for patients has not increased as expected. We propose the multi-arm, multi-stage trial design as a way to evaluate treatments faster and more efficiently than current standard trial designs. By using intermediate outcomes and testing a number of new agents (and combinations) simultaneously, the new design requires fewer patients. Three trials using this methodology are presented.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Cancer Research Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | JNCI Journal of the National Cancer Institute | ||||
Publisher: | Oxford University Press | ||||
ISSN: | 0027-8874 | ||||
Official Date: | 2008 | ||||
Dates: |
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Volume: | 100 | ||||
Number: | 17 | ||||
Page Range: | pp. 1204-1214 | ||||
DOI: | 10.1093/jnci/djn267 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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