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Perceived negative attitude of others predicts transition to psychosis in patients at risk of psychosis
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Salokangas, R. K. R., Patterson, Paul, Heinimaa, M., Svirskis, T., From, T., Vaskelainen, L., Klosterkötter, J., Ruhrmann, S., von Reventlow, H.G., Juckel, G., Linszen, D., Dingemans, P. and Birchwood, M. J. (2012) Perceived negative attitude of others predicts transition to psychosis in patients at risk of psychosis. European Psychiatry, 27 (4). pp. 264-266. doi:10.1016/j.eurpsy.2010.11.004 ISSN 0924-9338.
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Official URL: http://dx.doi.org/10.1016/j.eurpsy.2010.11.004
Abstract
Aim
Our previous study (Salokangas et al., 2009) suggested that the subjective experience of negative attitude of others (NAO) towards oneself is an early indicator of psychotic development. The aim of this prospective follow-up study was to test this hypothesis.
Methods
A total of 55 young psychiatric outpatients assessed as being at current risk of psychosis (CROP) were followed for up to 60 months and rates of transition to psychosis (TTP) identified. CROP was assessed employing the Bonn Scale for assessment of basic symptoms (Schultze-Lutter and Klosterkötter, 2002) and the Structured Interview for prodromal symptoms (Miller et al., 2002). TTP was defined by a psychotic episode lasting for more than one week. Associations between NAO at baseline and TTP were analyzed by a Cox regression survival analysis.
Results
Eight (14.5%) TTP were identified: four (57.1%) within seven NAO patients and four (8.7%) within forty-six non-NAO patients. In the multivariate Cox regression analysis, NAO at baseline significantly (P = 0.007) predicted TTP.
Conclusion
The prospective follow-up results support our hypothesis that subjective experience of NAO is an early indicator of psychotic in development.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | European Psychiatry | ||||
| Publisher: | Elsevier | ||||
| ISSN: | 0924-9338 | ||||
| Official Date: | 2012 | ||||
| Dates: |
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| Volume: | 27 | ||||
| Number: | 4 | ||||
| Page Range: | pp. 264-266 | ||||
| DOI: | 10.1016/j.eurpsy.2010.11.004 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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