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A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications
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Corrie, Pippa G., Bulusu, R., Wilson, C. B., Armstrong, G., Bond, S., Hardy, R., Lao-Sirieix, S., Parashar, D., Ahmad, A., Daniel, F., Hill, M., Wilson, G., Blesing, C., Moody, A. M., McAdam, K. and Osborne, M. (2012) A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications. British Journal of Cancer, 107 (4). pp. 585-587. bjc2012318a. doi:10.1038/bjc.2012.318 ISSN 0007-0920.
An open access version can be found in:
Official URL: http://dx.doi.org/10.1038/bjc.2012.318
Abstract
ABSTRACT
Background:
Pyridoxine is frequently used to treat capecitabine-induced hand–foot syndrome (HFS), although the evidence of benefit is lacking. We performed a randomised placebo-controlled trial to determine whether pyridoxine could avoid the need for capecitabine dose modifications and improve outcomes.
Methods:
A total of 106 patients planned for palliative single-agent capecitabine (53 in each arm, 65%/ 35% colorectal/breast cancer) were randomised to receive either concomitant pyridoxine (50 mg po) or matching placebo three times daily.
Results:
Compared with placebo, pyridoxine use was associated with an increased rate of avoiding capecitabine dose modifications (37% vs 23%, relative risk 0.59, 95% CI 0.29, 1.20, P=0.15) and fewer grade 3/4 HFS-related adverse events (9% vs 17%, odds ratio 0.51, 95% CI 0.15–1.6, P=0.26). Use of pyridoxine did not improve response rate or progression-free survival.
Conclusion:
Pyridoxine may reduce the need for capecitabine dose modifications and the incidence of severe HFS, but does not impact on antitumour effect.
Item Type: | Journal Article | ||||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Cancer Research Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | British Journal of Cancer | ||||||||||
Publisher: | Nature Publishing Group | ||||||||||
ISSN: | 0007-0920 | ||||||||||
Official Date: | 7 August 2012 | ||||||||||
Dates: |
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Volume: | 107 | ||||||||||
Number: | 4 | ||||||||||
Page Range: | pp. 585-587 | ||||||||||
Article Number: | bjc2012318a | ||||||||||
DOI: | 10.1038/bjc.2012.318 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Open Access Version: |
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