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Split-course chemoradiation therapy : an effective alternative treatment of anal cancer in elderly patients
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Vivekanandan, S., Whitfield, G.A., Parashar, D., Jephcott, C.R. and Wilson, C.B. (2012) Split-course chemoradiation therapy : an effective alternative treatment of anal cancer in elderly patients. International Journal of Radiation Oncology*Biology*Physics, 84 (3). S354. doi:10.1016/j.ijrobp.2012.07.934 ISSN 0360-3016.
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Official URL: http://dx.doi.org/10.1016/j.ijrobp.2012.07.934
Abstract
Combined Chemotherapy and Radiation Therapy (CRT) results in better local control and colostomy free survival than radiation therapy alone in squamous cell carcinomas (SCC) of the anus. Full dose CRT of 50.4 Gy in 28 fractions with concurrent chemotherapy in anal SCC can result in a 3-year relapse free survival (RFS) of 75%. However, frail elderly patients or those with co-morbidities and poor performance status cannot tolerate full-dose CRT due to toxicities. The purpose of this study is to assess the effectiveness of a split-course CRT regime in the radical treatment of anal SCC in patients over 70 in whom poor performance status, co-morbidity or a combination precluded full-dose radical CRT.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Cancer Research Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | International Journal of Radiation Oncology*Biology*Physics | ||||
Publisher: | Elsevier | ||||
ISSN: | 0360-3016 | ||||
Official Date: | 1 November 2012 | ||||
Dates: |
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Volume: | 84 | ||||
Number: | 3 | ||||
Article Number: | S354 | ||||
DOI: | 10.1016/j.ijrobp.2012.07.934 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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