Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Synthetic polynucleotides and interferon induction

Tools
- Tools
+ Tools

Folayan, Joseph Ololade (1973) Synthetic polynucleotides and interferon induction. PhD thesis, University of Warwick.

[img]
Preview
PDF
WRAP_Thesis_Folayan_1973.pdf - Requires a PDF viewer.

Download (33Mb) | Preview
Official URL: http://webcat.warwick.ac.uk/record=b1736433~S1

Request Changes to record.

Abstract

Modified cytidylic and adenylic acids have been synthesised and studied as possible inducers of interferon when hybridised with the appropriate polynucleotides.
The report in this thesis describes:
a) The synthesis and characterisation of poly (5-fluorocytidylic acid) to complete the series of 5-halo substituted cytidylic acids. Poly(I). poly(fl⁵C) was interferon inducing.
b) The synthesis and characterisation of poly (5-dimethylaminocytidylic acid) in which a substituent other than the halogens was inserted into the 5-postion of cytidine. The polymer formed a 1:1 hybrid with poly(I) and the hybrid was a good inducer of interferon.
c) The synthesis and characterisation of poly (8-oxyadenylic acid) which was one of the first 8-substituted homopolymers of adenosine.

Item Type: Thesis or Dissertation (PhD)
Subjects: Q Science > QD Chemistry
Library of Congress Subject Headings (LCSH): Interferon, Nucleic acids -- Synthesis, Interferon inducers, Nucleotides
Official Date: 1973
Dates:
DateEvent
1973Submitted
Institution: University of Warwick
Theses Department: Department of Chemistry
Thesis Type: PhD
Publication Status: Unpublished
Supervisor(s)/Advisor: Hutchinson, D. W.(David Wesley)
Sponsors: Nigeria
Extent: 121 leaves
Language: eng

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us